1,6-dimethyl-5-ethoxycarbonyl-4-(2-(triphenylphosphoranylideneamino)phenyl)-3,4-dihydropyrimidin-2(1H)-one

Base Information

• Chemical Name: 1,6-dimethyl-5-ethoxycarbonyl-4-(2-(triphenylphosphoranylideneamino)phenyl)-3,4-dihydropyrimidin-2(1H)-one
• CAS No.: 1248635-29-1
• Molecular Formula: C₃₃H₃₂N₃O₃P
• Molecular Weight: 549.609
• Mol file: 1248635-29-1.mol

Synonyms:1,6-dimethyl-5-ethoxycarbonyl-4-(2-(triphenylphosphoranylideneamino)phenyl)-3,4-dihydropyrimidin-2(1H)-one

Chemical Property of 1,6-dimethyl-5-ethoxycarbonyl-4-(2-(triphenylphosphoranylideneamino)phenyl)-3,4-dihydropyrimidin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,6-dimethyl-5-ethoxycarbonyl-4-(2-(triphenylphosphoranylideneamino)phenyl)-3,4-dihydropyrimidin-2(1H)-one

There total 1 articles about 1,6-dimethyl-5-ethoxycarbonyl-4-(2-(triphenylphosphoranylideneamino)phenyl)-3,4-dihydropyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(2-azidophenyl)-1,6-dimethyl-5-ethoxycarbonyl-3,4-dihydropyrimidin-2(1H)-one (1248635-19-9) + triphenylphosphine (603-35-0) → 1,6-dimethyl-5-ethoxycarbonyl-4-(2-(triphenylphosphoranylideneamino)phenyl)-3,4-dihydropyrimidin-2(1H)-one (1248635-29-1)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2010.08.046

Reference yield: 81.0%

1,6-dimethyl-5-ethoxycarbonyl-4-(2-(triphenylphosphoranylideneamino)phenyl)-3,4-dihydropyrimidin-2(1H)-one (1248635-29-1) + m-Chlorobenzoyl chloride (618-46-2) → 6-(3-chlorophenyl)-2,3-dimethyl-1-ethoxycarbonyl-3,11b-dihydro-4H-pyrimido[1,6-c]quinazolin-4-one (1248635-90-6)

Guidance literature:

With triethylamine; In acetonitrile; for 4h; Reflux;

DOI:10.1016/j.tet.2010.08.046

Reference yield: 81.0%

1,6-dimethyl-5-ethoxycarbonyl-4-(2-(triphenylphosphoranylideneamino)phenyl)-3,4-dihydropyrimidin-2(1H)-one (1248635-29-1) + benzoyl chloride (98-88-4) → 2,3-dimethyl-1-ethoxycarbonyl-6-phenyl-3,11b-dihydro-4H-pyrimido[1,6-c]quinazolin-4-one (1248635-79-1)

Guidance literature:

With triethylamine; In acetonitrile; for 6h; Reflux;

DOI:10.1016/j.tet.2010.08.046

upstream raw materials:

4-(2-azidophenyl)-1,6-dimethyl-5-ethoxycarbonyl-3,4-dihydropyrimidin-2(1H)-one

triphenylphosphine

Downstream raw materials:

2,3-dimethyl-1-ethoxycarbonyl-6-(4-fluorophenyl)-3,11b-dihydro-4H-pyrimido[1,6-c]quinazolin-4-one

6-(3-chlorophenyl)-2,3-dimethyl-1-ethoxycarbonyl-3,11b-dihydro-4H-pyrimido[1,6-c]quinazolin-4-one

6-(2-chlorophenyl)-2,3-dimethyl-1-ethoxycarbonyl-3,11b-dihydro-4H-pyrimido[1,6-c]quinazolin-4-one

2,3-dimethyl-1-ethoxycarbonyl-6-phenyl-3,11b-dihydro-4H-pyrimido[1,6-c]quinazolin-4-one