thioacetic acid S-{(S)-6-[((S)-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl} ester

Base Information

Chemical Name:thioacetic acid S-{(S)-6-[((S)-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl} ester
CAS No.:1428535-81-2
Molecular Formula:C₂₁H₂₇N₃O₄S
Molecular Weight:417.529
Hs Code.:

Synonyms:thioacetic acid S-{(S)-6-[((S)-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl} ester

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Chemical Property of thioacetic acid S-{(S)-6-[((S)-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl} ester

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Technology Process of thioacetic acid S-{(S)-6-[((S)-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl} ester

There total 13 articles about thioacetic acid S-{(S)-6-[((S)-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147751-02-8
(S)-1,2,3,6-tetrahydro-6-oxopyridine-2(S)-carboxylic acid

: 1428536-19-9
thioacetic acid S-((-S)-6-amino-6-phenylcarbamoyl-hexyl) ester trifluoroacetate

: 1428535-81-2
thioacetic acid S-{(S)-6-[((S)-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl} ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm5008209

Reference yield:

: 62-53-3
aniline

: 1428535-81-2
thioacetic acid S-{(S)-6-[((S)-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl} ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 20 °C

1.2: 2 h / 20 °C

2.1: 2,2'-azobis(isobutyronitrile) / 1,4-dioxane / 1 h / 75 °C

3.1: dichloromethane / 0 - 20 °C

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With 2,2'-azobis(isobutyronitrile); benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm5008209

Reference yield:

: 5183-26-6
diethyl acetamido(5-bromopentyl)malonate

: 1428535-81-2
thioacetic acid S-{(S)-6-[((S)-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl} ester

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydroxide / water; ethanol / 5 h / 0 °C

2: toluene / 4 h / Reflux

3: sodium hydroxide / water; ethanol / 4 h / 0 °C

4: aminoacylase; cobalt(II) chloride hexahydrate / water / 24 h / 38 °C / pH 7

5: triethylamine / water; tetrahydrofuran / 20 h / 20 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxybenzotriazol-hydrate / tetrahydrofuran / 20 °C

7: ethanol / 20 °C

8: dichloromethane / 0 - 20 °C

9: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With aminoacylase; cobalt(II) chloride hexahydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm5008209