2-Fluoro-4-methylphenylboronic acid pinacol ester

Base Information

• Chemical Name: 2-Fluoro-4-methylphenylboronic acid pinacol ester
• CAS No.: 1165936-03-7
• Molecular Formula: C₁₃H₁₈BFO₂
• Molecular Weight: 236.094
• Mol file: 1165936-03-7.mol

Synonyms:2-(2-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2-Fluoro-4-methylphenylboronic acid pinacol ester

Chemical Property:

• Melting Point: 58-60℃
• Boiling Point: 300.9±35.0 °C(Predicted)
• Density: 1.04±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(2-Fluoro-4-methylphenyl)boronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Fluoro-4-methylphenylboronic acid pinacol ester

There total 12 articles about 2-Fluoro-4-methylphenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-fluoro-4-methylphenylboronic acid (170981-26-7) + 2,3-dimethyl-2,3-butane diol (76-09-5) → 2-(2-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1165936-03-7)

Guidance literature:

With toluene-4-sulfonic acid; In diethyl ether; at 20 ℃; for 18h;

Reference yield: 90.0%

4-bromo-3-fluorotoluene (452-74-4) + bis(pinacol)diborane (73183-34-3) → 2-(2-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1165936-03-7)

Guidance literature:

With bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride; potassium propionate; In ethyl acetate; Reflux;

Reference yield: 80.0%

C13H17BClFO2 → 2-(2-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1165936-03-7)

Guidance literature:

With potassium fluoride; palladium diacetate; In tetrahydrofuran; water; at 20 ℃; for 5h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol5028738

upstream raw materials:

4-bromo-3-fluorotoluene

bis(pinacol)diborane

2-fluoro-4-methylphenylboronic acid

2,3-dimethyl-2,3-butane diol