1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-morpholin-4-yl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Base Information

Chemical Name:1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-morpholin-4-yl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide
CAS No.:1383717-48-3
Molecular Formula:C₂₄H₃₀N₆O₄
Molecular Weight:466.54
Hs Code.:

Synonyms:1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-morpholin-4-yl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

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Chemical Property of 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-morpholin-4-yl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

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Technology Process of 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-morpholin-4-yl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

There total 9 articles about 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-morpholin-4-yl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1383718-16-8
[3-(2,4-dihydroxy-5-isopropyl-phenyl)-5-ethylcarbamoyl-3H-[1,2,3]triazol-4-yl]-(4-morpholin-4-yl-phenyl)-carbamic acid tert-butyl ester

: 1383717-48-3
1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-morpholin-4-yl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 1155371-80-4
(((4-isopropyl-1,3-phenylene)bis(oxy))bis(methylene))dibenzene

: 1383717-48-3
1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-morpholin-4-yl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid; acetic acid / 0.67 h / 70 - 80 °C

2.1: hydrogenchloride; tin(ll) chloride / ethanol; water / 4 h / 80 °C

2.2: 0 °C

3.1: trimethylsilylazide; tert.-butylnitrite / acetonitrile / 13 h / 0 - 20 °C

4.1: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5.1: methanol / 24 h / 80 °C / sealed tube

6.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 1 h

7.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With hydrogenchloride; tert.-butylnitrite; trimethylsilylazide; hydrogen; nitric acid; acetic acid; trifluoroacetic acid; tin(ll) chloride; chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; 10 wt% Pd(OH)2 on carbon; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1383717-81-4
1,5-bis-benzyloxy-2-isopropyl-4-azido-benzene

: 1383717-48-3
1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-morpholin-4-yl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: methanol / 24 h / 80 °C / sealed tube

3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 1 h

4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With hydrogen; trifluoroacetic acid; chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; 10 wt% Pd(OH)2 on carbon; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;