6-(tert-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-en-1-ol

Base Information

Chemical Name:6-(tert-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-en-1-ol
CAS No.:935252-93-0
Molecular Formula:C₃₀H₄₂O₄Si
Molecular Weight:494.747
Hs Code.:

6-(<i>tert</i>-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-en-1-ol

Synonyms:6-(tert-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-en-1-ol

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Chemical Property of 6-(tert-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-en-1-ol

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Technology Process of 6-(tert-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-en-1-ol

There total 11 articles about 6-(tert-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 935253-03-5
6-(tert-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-enoic acid methyl ester

: 935252-93-0
6-(tert-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 2h;
DOI:10.1021/ol0700862

Reference yield:

: 935252-96-3
3-allyl-butane-1,2,4-triol

: 935252-93-0
6-(tert-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-en-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 75 percent / p-TsOH / ethyl acetate / 12 h / 20 °C

2: 97 percent / pyridine / 0 - 20 °C

3: ozone / methanol; CH₂Cl₂ / -78 °C

4: 10.3 g / NaBH₄ / methanol; CH₂Cl₂ / -78 - -20 °C

5: 91 percent / imidazole / dimethylformamide / 4 h / 20 °C

6: 95 percent / K₂CO₃ / methanol / 72 h / 20 °C

7: 95 percent / [bis(acetoxy)iodo]benzene; TEMPO / CH₂Cl₂ / 1.5 h / 20 °C

8: 94 percent / CH₂Cl₂ / 12 h / 20 °C

9: 86 percent / i-Bu₂AlH / toluene; CH₂Cl₂ / 2 h / -78 °C

With pyridine; 1H-imidazole; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium tetrahydroborate; [bis(acetoxy)iodo]benzene; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol0700862

Reference yield:

: 935252-97-4
2-(1,4-dioxa-spiro[4.5]dec-2-yl)-pent-4-en-1-ol

: 935252-93-0
6-(tert-butyl-diphenyl-silanyloxy)-4-(1,4-dioxa-spiro[4.5]dec-2-yl)-hex-2-en-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / pyridine / 0 - 20 °C

2: ozone / methanol; CH₂Cl₂ / -78 °C

3: 10.3 g / NaBH₄ / methanol; CH₂Cl₂ / -78 - -20 °C

4: 91 percent / imidazole / dimethylformamide / 4 h / 20 °C

5: 95 percent / K₂CO₃ / methanol / 72 h / 20 °C

6: 95 percent / [bis(acetoxy)iodo]benzene; TEMPO / CH₂Cl₂ / 1.5 h / 20 °C

7: 94 percent / CH₂Cl₂ / 12 h / 20 °C

8: 86 percent / i-Bu₂AlH / toluene; CH₂Cl₂ / 2 h / -78 °C

With pyridine; 1H-imidazole; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium tetrahydroborate; [bis(acetoxy)iodo]benzene; diisobutylaluminium hydride; potassium carbonate; ozone; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol0700862