2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[3''''-(2''''-tert-butylaminosulfonylphenyl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

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Chemical Name:2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[3''''-(2''''-tert-butylaminosulfonylphenyl)phenyl]-1,4:3,6-dianhydro-D-sorbitole
CAS No.:745794-60-9
Molecular Formula:C₃₁H₃₃N₃O₇S
Molecular Weight:591.685
Hs Code.:

Synonyms:2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[3''''-(2''''-tert-butylaminosulfonylphenyl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

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Chemical Property of 2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[3''''-(2''''-tert-butylaminosulfonylphenyl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

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Technology Process of 2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[3''''-(2''''-tert-butylaminosulfonylphenyl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

There total 6 articles about 2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[3''''-(2''''-tert-butylaminosulfonylphenyl)phenyl]-1,4:3,6-dianhydro-D-sorbitole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150691-04-6
2-(tert-butylamino)sulfonylphenylboronic acid

: 745794-60-9
2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[3''''-(2''''-tert-butylaminosulfonylphenyl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: Multi-step reaction with 3 steps

1: 38 percent / PPh₃; Ba(OH)2*8H₂O / Pd₂(dba)3 / 1,2-dimethoxy-ethane / 16 h / Heating

2: H₂ / Pd(OH)2/C / methanol; ethyl acetate / 750.06 Torr

3: 214 mg / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 40 °C

With barium dihydroxide; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium dihydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethyl acetate; 1: Suzuki cross coupling / 3: Mitsunobu reaction;

Reference yield:

: 183624-93-3
(3R,3aR,6R,6aR)-6-benzyloxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol

: 745794-60-9
2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[3''''-(2''''-tert-butylaminosulfonylphenyl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / CuI; 1,10-phenanthroline; Cs₂CO₃ / toluene / 24 h / Heating

2: 38 percent / PPh₃; Ba(OH)2*8H₂O / Pd₂(dba)3 / 1,2-dimethoxy-ethane / 16 h / Heating

3: H₂ / Pd(OH)2/C / methanol; ethyl acetate / 750.06 Torr

4: 214 mg / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 40 °C

With barium dihydroxide; copper(l) iodide; 1,10-Phenanthroline; di-isopropyl azodicarboxylate; hydrogen; caesium carbonate; triphenylphosphine; palladium dihydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethyl acetate; toluene; 2: Suzuki cross coupling / 4: Mitsunobu reaction;

Reference yield:

: 641-74-7
1,4:3,6-dianhydro-D-mannitol

: 745794-60-9
2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[3''''-(2''''-tert-butylaminosulfonylphenyl)phenyl]-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 80 °C

1.2: 48 percent / TBAI / dimethylformamide / 18 h / 20 °C

2.1: 51 percent / CuI; 1,10-phenanthroline; Cs₂CO₃ / toluene / 24 h / Heating

3.1: 38 percent / PPh₃; Ba(OH)2*8H₂O / Pd₂(dba)3 / 1,2-dimethoxy-ethane / 16 h / Heating

4.1: H₂ / Pd(OH)2/C / methanol; ethyl acetate / 750.06 Torr

5.1: 214 mg / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 40 °C

With barium dihydroxide; copper(l) iodide; 1,10-Phenanthroline; di-isopropyl azodicarboxylate; hydrogen; sodium hydride; caesium carbonate; triphenylphosphine; palladium dihydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 3.1: Suzuki cross coupling / 5.1: Mitsunobu reaction;