Butyric acid (E)-(R)-1-methyl-3-phenyl-allyl ester

Base Information

• Chemical Name: Butyric acid (E)-(R)-1-methyl-3-phenyl-allyl ester
• CAS No.: 124219-14-3
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.296
• Mol file: 124219-14-3.mol

Synonyms:Butyric acid (E)-(R)-1-methyl-3-phenyl-allyl ester

Chemical Property of Butyric acid (E)-(R)-1-methyl-3-phenyl-allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Butyric acid (E)-(R)-1-methyl-3-phenyl-allyl ester

There total 6 articles about Butyric acid (E)-(R)-1-methyl-3-phenyl-allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2,2-trifluoroethylbutyrate (371-27-7) + rac-(Z)-4-phenylbut-3-en-2-ol (104974-60-9) → (S,Z)-4-phenylbut-3-en-2-yl butyrate (124219-14-3,140390-65-4)

Guidance literature:

With chlorodicarbonyl(1-(isopropylamino)-2,3,4,5-tetraphenylcyclopentadienyl) ruthenium (II); potassium tert-butylate; sodium carbonate; In tetrahydrofuran; at 25 ℃; for 24h; enantioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1039/c7ob02181j

Reference yield:

vinyl n-butyrate (123-20-6,24991-31-9) + ethyl (E)-1-phenylbut-1-en-3-ol (36004-04-3) → Butyric acid (E)-(R)-1-methyl-3-phenyl-allyl ester (124219-14-3)

Guidance literature:

With Burkholderia cepacia lipase; C₃₆H₇₃O₁₄S^(1-)*C₇H₁₀N⁽¹⁺⁾; at 35 ℃; for 0.333333h; Reagent/catalyst; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.tet.2018.12.028

Reference yield:

4-phenyl-but-3-yn-2-ol (73922-81-3,81555-86-4,104597-03-7,5876-76-6) → (S,Z)-4-phenylbut-3-en-2-yl butyrate (124219-14-3,140390-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / P₂ Ni

2: diethyl ether / 167 h / Ambient temperature; porcine pancreatic lipase

With hydrogen; P₂ Ni; In diethyl ether;

DOI:10.1021/jo00037a049

upstream raw materials:

2,2,2-trifluoroethylbutyrate

rac-(Z)-4-phenylbut-3-en-2-ol

4-phenyl-but-3-yn-2-ol

lithium phenylacetylide