(2S,3R)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide

Base Information

Chemical Name:(2S,3R)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide
CAS No.:246236-74-8
Molecular Formula:C₂₅H₂₅NO₂
Molecular Weight:371.479
Hs Code.:

Synonyms:(2S,3R)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide

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Chemical Property of (2S,3R)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide

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Technology Process of (2S,3R)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide

There total 3 articles about (2S,3R)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 246236-70-4
(S,S)-(E)-N-cinnamoyl-bis(α-methylbenzyl)amine

: 246236-74-8
(2S,3R)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide

: 246236-72-6
(2R,3S)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide

Guidance literature:: With tert.-butylhydroperoxide; n-butyllithium; In tetrahydrofuran; hexane; toluene; at 20 ℃; for 12h;
DOI:10.1016/S0040-4039(99)01260-5

Reference yield:

: 21003-56-5,21003-57-6,23294-41-9,42287-48-9,56210-72-1,10024-74-5
(1S,1'S)-bis(1-phenylethyl)amine

: 246236-74-8
(2S,3R)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / H₂O; CH₂Cl₂ / 0.5 h / 20 °C

2: 32 percent / t-butylhydroperoxide; butyllithium / toluene; tetrahydrofuran; hexane / 12 h / 20 °C

With tert.-butylhydroperoxide; sodium hydroxide; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; water; toluene; 1: Acylation / 2: Oxidation;
DOI:10.1016/S0040-4039(99)01260-5

Reference yield:

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 246236-74-8
(2S,3R)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / H₂O; CH₂Cl₂ / 0.5 h / 20 °C

2: 32 percent / t-butylhydroperoxide; butyllithium / toluene; tetrahydrofuran; hexane / 12 h / 20 °C

With tert.-butylhydroperoxide; sodium hydroxide; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; water; toluene; 1: Acylation / 2: Oxidation;
DOI:10.1016/S0040-4039(99)01260-5