Technology Process of ethyl [(7R)-7-[[(4-fluorophenyl)sulfonyl]amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate
There total 8 articles about ethyl [(7R)-7-[[(4-fluorophenyl)sulfonyl]amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl [(7R)-7-amino-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate hydrochloride;
With
sodium carbonate;
In
Isopropyl acetate; water;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
4-Fluorobenzenesulfonyl chloride;
In
Isopropyl acetate; water;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/jo202620r
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / tetrahydrofuran / 2.33 h / 65 - 67 °C / Inert atmosphere
1.2: 3 h / 10 - 20 °C / Inert atmosphere
2.1: bis(1,5-cyclooctadiene)diiridium(I) dichloride / N,N-dimethyl-formamide / 7 h / 85 °C / Inert atmosphere
3.1: CDX-017 enzyme; pyridoxal 5'-phosphate / water; dimethyl sulfoxide / 52 h / 45 °C / pH 8.5 / Inert atmosphere; triethanolamine/isopropylamine buffer; Enzymatic reaction
3.2: 2 h / pH 6 / Inert atmosphere
4.1: sodium carbonate / Isopropyl acetate; water / 0.08 h / 20 °C / Inert atmosphere
4.2: 2 h / 20 °C / Inert atmosphere
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; CDX-017 enzyme; pyridoxal 5'-phosphate; potassium tert-butylate; sodium carbonate;
In
tetrahydrofuran; Isopropyl acetate; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo202620r
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene / 16 h / Reflux; Inert atmosphere
2.1: sulfuric acid / 2.5 h / 90 - 92 °C / Inert atmosphere
2.2: 5 - 18 °C / pH 7 / Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran / 2.33 h / 65 - 67 °C / Inert atmosphere
3.2: 3 h / 10 - 20 °C / Inert atmosphere
4.1: bis(1,5-cyclooctadiene)diiridium(I) dichloride / N,N-dimethyl-formamide / 7 h / 85 °C / Inert atmosphere
5.1: CDX-017 enzyme; pyridoxal 5'-phosphate / water; dimethyl sulfoxide / 52 h / 45 °C / pH 8.5 / Inert atmosphere; triethanolamine/isopropylamine buffer; Enzymatic reaction
5.2: 2 h / pH 6 / Inert atmosphere
6.1: sodium carbonate / Isopropyl acetate; water / 0.08 h / 20 °C / Inert atmosphere
6.2: 2 h / 20 °C / Inert atmosphere
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; sulfuric acid; CDX-017 enzyme; pyridoxal 5'-phosphate; potassium tert-butylate; sodium carbonate;
In
tetrahydrofuran; Isopropyl acetate; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo202620r
