3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

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Chemical Name:3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine
CAS No.:429671-54-5
Molecular Formula:C₃₅H₃₉N₅O₆SSi
Molecular Weight:685.876
Hs Code.:

Synonyms:3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

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Chemical Property of 3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

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Technology Process of 3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

There total 1 articles about 3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 429671-52-3
(3R)-3-amino-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

: 429666-56-8
3-t-butyldiphenylsilyloxy-1-(4-carboxyl-1,3-thiazol-2-yl)azetidine

: 429671-54-5
3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

Guidance literature:: (3R)-3-amino-1-(p-nitrobenzyloxycarbonyl)pyrrolidine; 3-t-butyldiphenylsilyloxy-1-(4-carboxyl-1,3-thiazol-2-yl)azetidine; With diethyl cyanophosphonate; triethylamine; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 2h;

With sodium hydrogencarbonate; In DMF (N,N-dimethyl-formamide); water; ethyl acetate;

Reference yield: 98.0%

: 429671-54-5
3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

: 429671-56-7
3-hydroxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

Guidance literature:: 3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine; With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 ℃; for 1h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;