1-Pyrrolidinecarboxylic acid, 3-[[[2-(3-hydroxy-1-azetidinyl)-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester, (3R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 3-[[[2-(3-hydroxy-1-azetidinyl)-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester, (3R)-
CAS No.:429671-56-7
Molecular Formula:C19H21N5O6S
Molecular Weight:447.472
Hs Code.:
Mol file:429671-56-7.mol

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 3-[[[2-(3-hydroxy-1-azetidinyl)-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester, (3R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 3-[[[2-(3-hydroxy-1-azetidinyl)-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester, (3R)-

There total 2 articles about 1-Pyrrolidinecarboxylic acid, 3-[[[2-(3-hydroxy-1-azetidinyl)-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 429671-54-5
3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

: 429671-56-7
3-hydroxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

Guidance literature:: 3-t-butyldiphenylsilyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine; With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 ℃; for 1h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

Reference yield: 98.0%

: 429671-56-7
3-hydroxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

Guidance literature:

Reference yield: 97.0%

: 429671-56-7
3-hydroxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

: 124-63-0
methanesulfonyl chloride

: 3-methanesulfonyloxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

Guidance literature:: 3-hydroxy-1-{4-[(3R)-1-(p-nitrobenzyloxycarbonyl)-pyrrolidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine; methanesulfonyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.66667h;

With sodium hydrogencarbonate; In dichloromethane; water; ethyl acetate;