8-benzyl 1-ethyl (7S)-7-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}-2-cyanooctanedioate

Base Information

Chemical Name:8-benzyl 1-ethyl (7S)-7-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}-2-cyanooctanedioate
CAS No.:1417177-28-6
Molecular Formula:C₃₁H₃₉N₃O₈
Molecular Weight:581.666
Hs Code.:

Synonyms:8-benzyl 1-ethyl (7S)-7-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}-2-cyanooctanedioate

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Chemical Property of 8-benzyl 1-ethyl (7S)-7-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}-2-cyanooctanedioate

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Technology Process of 8-benzyl 1-ethyl (7S)-7-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}-2-cyanooctanedioate

There total 6 articles about 8-benzyl 1-ethyl (7S)-7-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}-2-cyanooctanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 865370-16-7
tert-butoxycarbonylamino-cyano-acetic acid ethyl ester

: 2(S)-2-(benzyloxycarbonylamino)-6-mesyloxycaproic acid benzyl ester

: 1417177-28-6
8-benzyl 1-ethyl (7S)-7-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}-2-cyanooctanedioate

Guidance literature:: tert-butoxycarbonylamino-cyano-acetic acid ethyl ester; With sodium ethanolate; In ethanol; at 60 ℃; for 0.5h;

2(S)-2-(benzyloxycarbonylamino)-6-mesyloxycaproic acid benzyl ester; In dimethyl sulfoxide; at 70 ℃; for 10h;
DOI:10.1021/bc3003327

Reference yield:

: 84246-49-1
2(S)-2-(benzyloxycarbonylamino)-6-hydroxyhexanoic acid, benzyl ester

: 1417177-28-6
8-benzyl 1-ethyl (7S)-7-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}-2-cyanooctanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 3 h / -78 - 20 °C

2.1: sodium ethanolate / ethanol / 0.5 h / 60 °C

2.2: 10 h / 70 °C

With sodium ethanolate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/bc3003327

Reference yield:

: 2212-75-1
N₂-[(benzyloxy)carbonyl]-L-lysine

: 1417177-28-6
8-benzyl 1-ethyl (7S)-7-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}-2-cyanooctanedioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; sodium nitroprusside / pH 9.5

2.1: triethylamine

3.1: triethylamine / dichloromethane / 3 h / -78 - 20 °C

4.1: sodium ethanolate / ethanol / 0.5 h / 60 °C

4.2: 10 h / 70 °C

With sodium nitroprusside; sodium ethanolate; triethylamine; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1021/bc3003327