[4-(3,5-bis(4-trifluoromethylphenyl)benzyloxy)-2-methylphenoxy]acetic acid methyl ester

Base Information

Chemical Name:[4-(3,5-bis(4-trifluoromethylphenyl)benzyloxy)-2-methylphenoxy]acetic acid methyl ester
CAS No.:870289-07-9
Molecular Formula:C₃₁H₂₄F₆O₄
Molecular Weight:574.52
Hs Code.:

Synonyms:[4-(3,5-bis(4-trifluoromethylphenyl)benzyloxy)-2-methylphenoxy]acetic acid methyl ester

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Chemical Property of [4-(3,5-bis(4-trifluoromethylphenyl)benzyloxy)-2-methylphenoxy]acetic acid methyl ester

Chemical Property:

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Technology Process of [4-(3,5-bis(4-trifluoromethylphenyl)benzyloxy)-2-methylphenoxy]acetic acid methyl ester

There total 5 articles about [4-(3,5-bis(4-trifluoromethylphenyl)benzyloxy)-2-methylphenoxy]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868835-06-7
[4-(3,5-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 870289-07-9
[4-(3,5-bis(4-trifluoromethylphenyl)benzyloxy)-2-methylphenoxy]acetic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; ethanol; at 170 ℃; for 0.166667h; microwave irradiation;
DOI:10.1016/j.bmcl.2006.02.079

Reference yield:

: 876-02-8
4-hydroxy-3-methylphenyl methyl ketone

: 870289-07-9
[4-(3,5-bis(4-trifluoromethylphenyl)benzyloxy)-2-methylphenoxy]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Cs₂CO₃ / acetonitrile / 20 °C

2: meta-chloroperbenzoic acid; p-TsOH / CH₂Cl₂ / 48 h / Heating

3: MeONa / methanol / 1 h / 20 °C

4: 95 percent / Cs₂CO₃ / acetonitrile / 18 h / 20 °C

5: aq. K₂CO₃; Pd(Ph₃P)4 / ethanol; dioxane / 0.17 h / 170 °C / microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; acetonitrile; 5: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.02.079

Reference yield:

: 317319-10-1
methyl (4-hydroxy-2-methylphenoxy)acetate

: 870289-07-9
[4-(3,5-bis(4-trifluoromethylphenyl)benzyloxy)-2-methylphenoxy]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Cs₂CO₃ / acetonitrile / 18 h / 20 °C

2: aq. K₂CO₃; Pd(Ph₃P)4 / ethanol; dioxane / 0.17 h / 170 °C / microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; In 1,4-dioxane; ethanol; acetonitrile; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.02.079