868835-06-7

Upstream product

• 145691-59-4 (3,5-dibromophenyl)methanol 
• 317319-10-1 methyl (4-hydroxy-2-methylphenoxy)acetate 
• 317319-09-8 (4-acetoxy-2-methylphenoxy)acetic acid methyl ester 
• 166953-80-6 (4-acetyl-2-methylphenoxy)acetic acid methyl ester 
• 56908-88-4 3,5-dibromobenzyl bromide 
• 876-02-8 4-hydroxy-3-methylphenyl methyl ketone 

Downstream Products

• 890137-71-0 [4-(4,4''-dichloro-[1,1';3',1'']terphenyl-5'-ylmethoxy)-2-methyl-phenoxy]-acetic acid methyl ester 
• 890137-69-6 [4-(4,4''-dimethoxy-[1,1';3',1'']terphenyl-5'-ylmethoxy)-2-methyl-phenoxy]-acetic acid methyl ester 
• 890137-64-1 [2-methyl-4-([1,1';3',1'']terphenyl-5'-ylmethoxy)-phenoxy]-acetic acid methyl ester 
• 868835-08-9 methyl [4-(3,5-diethynylbenzyloxy)-2-methylphenoxy]acetate 
• 870289-01-3 [4-(5-bromo-4'-methoxy-biphenyl-3-ylmethoxy)-2-methyl-phenoxy]-acetic acid methyl ester 
• 890137-74-3 [2-methyl-4-(4''-trifluoromethoxy-4-trifluoromethyl-[1,1';3',1'']terphenyl-5'-ylmethoxy)-phenoxy]-acetic acid methyl ester 
• 890137-73-2 [4-(3,4''-bis-trifluoromethyl-[1,1';3',1'']terphenyl-5'-ylmethoxy)-2-methyl-phenoxy]-acetic acid methyl ester 
• 890137-77-6 [2-methyl-4-(4-trifluoromethyl-[1,1';3',1'';4'',1''']quaterphenyl-5'-ylmethoxy)-phenoxy]-acetic acid methyl ester 
• 890137-75-4 [4-(4''-methoxy-4-trifluoromethyl-[1,1';3',1'']terphenyl-5'-ylmethoxy)-2-methyl-phenoxy]-acetic acid methyl ester 

Relevant academic research and scientific papers

Novel compounds, their preparation and use

Novel compounds of the general formula (I), in which the variables are as defined in claim 1, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compound

1,3,5-Trisubstituted aryls as highly selective PPARδ agonists

A series of highly potent and selective PPARδ agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 μM, making it a useful tool in studying the biological effects of selective PPARδ activation.

NOVEL COMPOUNDS, THEIR PREPARATION AND USE

Novel compounds of the general formula (I), in which the variables are as defined in claim 1, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compound

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPARδ .