3',5'-di-O-benzyl-2'-C-β-ethoxymethyluridine

Base Information

Chemical Name:3',5'-di-O-benzyl-2'-C-β-ethoxymethyluridine
CAS No.:948838-18-4
Molecular Formula:C₂₆H₃₀N₂O₇
Molecular Weight:482.533
Hs Code.:

Synonyms:3',5'-di-O-benzyl-2'-C-β-ethoxymethyluridine

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Chemical Property of 3',5'-di-O-benzyl-2'-C-β-ethoxymethyluridine

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Technology Process of 3',5'-di-O-benzyl-2'-C-β-ethoxymethyluridine

There total 10 articles about 3',5'-di-O-benzyl-2'-C-β-ethoxymethyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 948838-16-2
3',5'-di-O-benzyl-2'-O-(4-tert-butylbenzoyl)-2'-C-β-ethoxymethyluridine

: 948838-18-4
3',5'-di-O-benzyl-2'-C-β-ethoxymethyluridine

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 24h;
DOI:10.1021/ol071075b

Reference yield: 74.0%

: 948838-15-1
2'-O-benzoyl-3',5'-di-O-benzyl-2'-C-β-ethoxymethyluridine

: 948838-18-4
3',5'-di-O-benzyl-2'-C-β-ethoxymethyluridine

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 24h;
DOI:10.1021/ol071075b

Reference yield:

: 80795-53-5
(2S,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxytetrahydrofuran-3-ol

: 948838-18-4
3',5'-di-O-benzyl-2'-C-β-ethoxymethyluridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / Dess-Martin periodinane / CH₂Cl₂ / 24 h / 20 °C

2.1: HgCl₂; magnesium / tetrahydrofuran / 2 h / -20 °C

2.2: tetrahydrofuran / 40 h / -78 - 20 °C

3.1: 416 mg / DMAP; triethylamine / CH₂Cl₂ / 72 h / 20 °C

4.1: 1,1,1,3,3,3-hexamethyldisilazane; ammonium sulfate / 0.5 h / Heating

4.2: 68 percent / tin(IV) chloride / acetonitrile / 24 h / 20 °C

5.1: 92 percent / aq. NaOH / methanol / 24 h / 20 °C

With dmap; sodium hydroxide; ammonium sulfate; Dess-Martin periodane; magnesium; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; mercury dichloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol071075b