1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime

Base Information

Chemical Name:1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime
CAS No.:1335496-64-4
Molecular Formula:C₃₄H₄₄F₁₃NO₅SSi₂
Molecular Weight:881.943
Hs Code.:

Synonyms:1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime

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Chemical Property of 1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime

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Technology Process of 1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime

There total 5 articles about 1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1335496-61-1
1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one oxime

: 98-59-9
p-toluenesulfonyl chloride

: 1335496-64-4
1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1039/c1ob05748k

Reference yield:

: 1335496-60-0
1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one

: 1335496-64-4
1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 16 h / Reflux

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 0 - 25 °C / Inert atmosphere

With dmap; hydroxylamine hydrochloride; sodium acetate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1039/c1ob05748k

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1335496-64-4
1-(3,5-bis((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one O-(p-tosyl)oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 16 h / 25 °C

2.1: n-butyllithium / diethyl ether; hexane / 2 h / -40 - 5 °C / Inert atmosphere

2.2: 4 h / -50 - 25 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 16 h / Reflux

4.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 0 - 25 °C / Inert atmosphere

With 1H-imidazole; dmap; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; N-ethyl-N,N-diisopropylamine; In diethyl ether; ethanol; hexane; dichloromethane;
DOI:10.1039/c1ob05748k