N-(1-cyclohexyl-3-oxo-2-pyridin-2-yl-2,3-dihydro-1H-indazol-5-yl)-succinamic acid

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Chemical Name:N-(1-cyclohexyl-3-oxo-2-pyridin-2-yl-2,3-dihydro-1H-indazol-5-yl)-succinamic acid
CAS No.:1086029-56-2
Molecular Formula:C₂₂H₂₄N₄O₄
Molecular Weight:408.457
Hs Code.:

Synonyms:N-(1-cyclohexyl-3-oxo-2-pyridin-2-yl-2,3-dihydro-1H-indazol-5-yl)-succinamic acid

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Chemical Property of N-(1-cyclohexyl-3-oxo-2-pyridin-2-yl-2,3-dihydro-1H-indazol-5-yl)-succinamic acid

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Technology Process of N-(1-cyclohexyl-3-oxo-2-pyridin-2-yl-2,3-dihydro-1H-indazol-5-yl)-succinamic acid

There total 6 articles about N-(1-cyclohexyl-3-oxo-2-pyridin-2-yl-2,3-dihydro-1H-indazol-5-yl)-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-30-5
succinic acid anhydride

: 1086029-66-4
5-amino-1-cyclohexyl-2-pyridin-2-yl-1,2-dihydro-indazol-3-one

: 1086029-56-2
N-(1-cyclohexyl-3-oxo-2-pyridin-2-yl-2,3-dihydro-1H-indazol-5-yl)-succinamic acid

Guidance literature:: succinic acid anhydride; 5-amino-1-cyclohexyl-2-pyridin-2-yl-1,2-dihydro-indazol-3-one; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;

With water; sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: 2516-96-3
2-chloro-5-nitrobenzoic acid

: 1086029-56-2
N-(1-cyclohexyl-3-oxo-2-pyridin-2-yl-2,3-dihydro-1H-indazol-5-yl)-succinamic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.1 h / 120 °C / Microwave heating

1.3: Acidic aqueous solution

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 0.03 h / 20 °C

2.2: 64.5 h

3.1: bis-[(trifluoroacetoxy)iodo]benzene / acetonitrile / 2 h / 20 °C

3.2: 69 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; bis-[(trifluoroacetoxy)iodo]benzene; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1086029-92-6
1-cyclohexyl-5-nitro-2-pyridin-2-yl-1,2-dihydroindazol-3-one

: 1086029-56-2
N-(1-cyclohexyl-3-oxo-2-pyridin-2-yl-2,3-dihydro-1H-indazol-5-yl)-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;