(1'R,2'S,4'S,5'S)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-[(dibenzylphosphato)methyl]-2-(dibenzyloxyphosphato)bicyclo[3.1.0]hexane

Base Information

Chemical Name:(1'R,2'S,4'S,5'S)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-[(dibenzylphosphato)methyl]-2-(dibenzyloxyphosphato)bicyclo[3.1.0]hexane
CAS No.:630103-32-1
Molecular Formula:C₄₀H₄₀ClN₅O₈P₂
Molecular Weight:816.187
Hs Code.:

Synonyms:(1'R,2'S,4'S,5'S)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-[(dibenzylphosphato)methyl]-2-(dibenzyloxyphosphato)bicyclo[3.1.0]hexane

Suppliers and Price of (1'R,2'S,4'S,5'S)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-[(dibenzylphosphato)methyl]-2-(dibenzyloxyphosphato)bicyclo[3.1.0]hexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1'R,2'S,4'S,5'S)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-[(dibenzylphosphato)methyl]-2-(dibenzyloxyphosphato)bicyclo[3.1.0]hexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1'R,2'S,4'S,5'S)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-[(dibenzylphosphato)methyl]-2-(dibenzyloxyphosphato)bicyclo[3.1.0]hexane

There total 6 articles about (1'R,2'S,4'S,5'S)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-[(dibenzylphosphato)methyl]-2-(dibenzyloxyphosphato)bicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Phosphorous acid (1R,2S,4S,5S)-4-(2-amino-6-chloro-purin-9-yl)-1-(bis-benzyloxy-phosphanyloxymethyl)-bicyclo[3.1.0]hex-2-yl ester dibenzyl ester

: 630103-32-1
(1'R,2'S,4'S,5'S)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-[(dibenzylphosphato)methyl]-2-(dibenzyloxyphosphato)bicyclo[3.1.0]hexane

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/jm030127+

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 630103-32-1
(1'R,2'S,4'S,5'S)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-[(dibenzylphosphato)methyl]-2-(dibenzyloxyphosphato)bicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-tetrazole / tetrahydrofuran / 4.5 h / 20 °C

2: 52 mg / m-chloroperbenzoic acid / CH₂Cl₂ / -78 - 20 °C

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030127+

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 630103-32-1
(1'R,2'S,4'S,5'S)-4-(2-amino-6-chloro-9H-purin-9-yl)-1-[(dibenzylphosphato)methyl]-2-(dibenzyloxyphosphato)bicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 18.5 h / 20 °C

2: 69 percent / BCl₃ / CH₂Cl₂ / 1 h / -40 °C

3: 1H-tetrazole / tetrahydrofuran / 4.5 h / 20 °C

4: 52 mg / m-chloroperbenzoic acid / CH₂Cl₂ / -78 - 20 °C

With 1H-tetrazole; di-isopropyl azodicarboxylate; boron trichloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jm030127+