Trifluoro-methanesulfonic acid 4-(4-amino-phenyl)-6-tert-butyl-3-cyano-pyridin-2-yl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid 4-(4-amino-phenyl)-6-tert-butyl-3-cyano-pyridin-2-yl ester
• CAS No.: 901123-53-3
• Molecular Formula: C₁₇H₁₆F₃N₃O₃S
• Molecular Weight: 399.394
• Mol file: 901123-53-3.mol

Synonyms:Trifluoro-methanesulfonic acid 4-(4-amino-phenyl)-6-tert-butyl-3-cyano-pyridin-2-yl ester

Chemical Property of Trifluoro-methanesulfonic acid 4-(4-amino-phenyl)-6-tert-butyl-3-cyano-pyridin-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trifluoro-methanesulfonic acid 4-(4-amino-phenyl)-6-tert-butyl-3-cyano-pyridin-2-yl ester

There total 4 articles about Trifluoro-methanesulfonic acid 4-(4-amino-phenyl)-6-tert-butyl-3-cyano-pyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Trifluoromethanesulfonic acid 6-tert-butyl-3-cyano-4-(4-nitro-phenyl)-pyridin-2-yl ester (894078-18-3) → Trifluoro-methanesulfonic acid 4-(4-amino-phenyl)-6-tert-butyl-3-cyano-pyridin-2-yl ester (901123-53-3)

Guidance literature:

Trifluoromethanesulfonic acid 6-tert-butyl-3-cyano-4-(4-nitro-phenyl)-pyridin-2-yl ester; With ethanol; water; tin(ll) chloride; at 70 ℃; for 0.5 - 2h;

With ammonia; In ethanol; water;

Reference yield:

6-tert-Butyl-4-(4-nitro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile (894078-17-2) → Trifluoro-methanesulfonic acid 4-(4-amino-phenyl)-6-tert-butyl-3-cyano-pyridin-2-yl ester (901123-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 2 h / 0 - 20 °C

2: ethanol; water; tin(ll) chloride / 0.5 - 2 h / 70 °C

With pyridine; ethanol; water; tin(ll) chloride; In dichloromethane;

Reference yield:

3,3-dimethyl-butan-2-one (75-97-8) → Trifluoro-methanesulfonic acid 4-(4-amino-phenyl)-6-tert-butyl-3-cyano-pyridin-2-yl ester (901123-53-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / 17 - 21 h / 20 °C / Heating / reflux

2: pyridine / dichloromethane / 2 h / 0 - 20 °C

3: ethanol; water; tin(ll) chloride / 0.5 - 2 h / 70 °C

With pyridine; ethanol; ammonium acetate; water; tin(ll) chloride; In ethanol; dichloromethane;

upstream raw materials:

Trifluoromethanesulfonic acid 6-tert-butyl-3-cyano-4-(4-nitro-phenyl)-pyridin-2-yl ester

6-tert-Butyl-4-(4-nitro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

3,3-dimethyl-butan-2-one

4-nitrobenzaldehdye