3-amino-6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-4-(methylamino)-picolinonitrile

Base Information

Chemical Name:3-amino-6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-4-(methylamino)-picolinonitrile
CAS No.:1315465-18-9
Molecular Formula:C₁₆H₁₅F₃N₄O₂
Molecular Weight:352.316
Hs Code.:

Synonyms:3-amino-6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-4-(methylamino)-picolinonitrile

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Chemical Property of 3-amino-6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-4-(methylamino)-picolinonitrile

Chemical Property:

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Technology Process of 3-amino-6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-4-(methylamino)-picolinonitrile

There total 5 articles about 3-amino-6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-4-(methylamino)-picolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1104380-99-5
3-amino-6-chloro-4-(methylamino)-2-pyridinecarbonitrile

: 1245014-68-9
2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenoxy)ethanol

: 1315465-18-9
3-amino-6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-4-(methylamino)-picolinonitrile

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

: 50824-04-9
4-bromo-2-(trifluoromethyl)phenol

: 1315465-18-9
3-amino-6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-4-(methylamino)-picolinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / Reflux

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

3: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With potassium phosphate; potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; acetonitrile;

Reference yield:

: 944388-71-0
4-amino-6-chloro-3-nitropyridine-2-carbonitrile

: 1315465-18-9
3-amino-6-(4-(2-hydroxyethoxy)-3-(trifluoromethyl)phenyl)-4-(methylamino)-picolinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 5 h / 80 °C

2: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C

3: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With potassium phosphate; tin(II) chloride dihdyrate; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; ethanol; acetonitrile;