NO₂-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe

Base Information

• Chemical Name: NO₂-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe
• CAS No.: 1194837-34-7
• Molecular Formula: C₃₉H₅₄N₄O₇
• Molecular Weight: 690.88
• Mol file: 1194837-34-7.mol

Synonyms:NO₂-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe

Chemical Property of NO₂-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of NO₂-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe

There total 6 articles about NO₂-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

NH2-(Et)ACHA-(D)Phe-OMe (1194837-31-4) + NO2-(Et)ACHA-(D)Phe-OH (1194837-33-6) → NO2-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe (1194837-34-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

(R)-2-((1S,2R)-2-nitrocyclohexyl)butan-1-ol (1292320-61-6) → NO2-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe (1194837-34-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 24 h / 20 °C

2: hydrogen / Raney nickel / methanol / 16 h / 2068.65 Torr

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 48 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; Raney nickel; In methanol; dichloromethane;

Reference yield:

D-phenylalanine methyl ester hydrochloride (13033-84-6) → NO2-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe (1194837-34-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 24 h / 20 °C

2: hydrogen / Raney nickel / methanol / 16 h / 2068.65 Torr

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 48 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; Raney nickel; In methanol; dichloromethane;

upstream raw materials:

NH₂-(Et)ACHA-(D)Phe-OMe

NO₂-(Et)ACHA-(D)Phe-OH

tert-butyl (2R)-2-amino-3-phenyl-propanoate hydrochloride

D-phenylalanine methyl ester hydrochloride

Downstream raw materials:

NH₂-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe

Boc-(Et)ACHA-(D)Phe-(Et)ACHA-(D)Phe-OMe