Technology Process of 3-(3-fluorophenylsulfonyl)-8-iodoquinoline
There total 2 articles about 3-(3-fluorophenylsulfonyl)-8-iodoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-(3-fluorophenyl)sulfonylquinolin-8-amine;
With
trifluoroacetic acid;
at 25 ℃;
for 0.333333h;
With
tert.-butylnitrite;
In
acetonitrile;
at 0 ℃;
for 0.25h;
With
copper(l) iodide;
In
acetonitrile;
at 0 - 25 ℃;
for 1h;
- Guidance literature:
-
3-(3-fluorophenylsulfonyl)quinolin-8-amine trifluoroacetate;
With
n-Butyl nitrite;
In
acetonitrile;
at 0 - 5 ℃;
for 0.166667h;
With
tetra-(n-butyl)ammonium iodide;
In
acetonitrile;
at 0 ℃;
for 2h;
With
water; sodium thiosulfate;
In
dichloromethane;
- Guidance literature:
-
(3R)-piperidin-3-ol;
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
toluene;
at 50 ℃;
Inert atmosphere;
3-(3-fluorophenylsulfonyl)-8-iodoquinoline;
In
toluene;
at 100 ℃;
