607743-17-9

Basic information

• Product Name: 3-(3-fluorophenyl)sulfonylquinolin-8-amine
• Synonyms: 3-(3-fluorophenyl)sulfonylquinolin-8-amine
• CAS NO: 607743-17-9
• Molecular Weight: 302.329
• Mol File: 607743-17-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(3-fluorophenyl)sulfonylquinolin-8-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-fluorophenyl)sulfonylquinolin-8-amine(607743-17-9)
• EPA Substance Registry System: 3-(3-fluorophenyl)sulfonylquinolin-8-amine(607743-17-9)

Safety Data

• Hazardous Substances Data: 607743-17-9(Hazardous Substances Data)

Upstream product

• 1476063-09-8 8-acetamino-3-bromoquinoline 
• 607-35-2 8-nitroquinoline 
• 5341-07-1 8-nitro-3-bromoquinoline 
• 607743-25-9 3-(3-fluorophenylsulfonyl)-8-nitroquinoline 

Downstream Products

• 607743-41-9 3-(3-fluorophenylsulfonyl)-8-iodoquinoline 

Relevant articles and documents

Synthesis and structure activity relationship of 3-(arylsulfonyl)-8- (piperidin-4-yl amino)quinoline derivatives as 5-HT6 receptor antagonists

As part of our efforts to develop better therapies for the treatment of cognitive impairment associated with Alzheimer's disease and Schizophrenia, we have focused our research towards 5-HT6 receptor (5-HT6R) in order to identify potent and selective ligands for this purpose. Herein, we report the synthesis, structure activity relationship and biological evaluation of a novel series of 3-(arylsulfonyl)-8- (piperidin-4-yl amino)quinoline derivatives, as 5-HT6 receptor (5-HT6R) antagonists. In this work, we have shown that moving from aryl sulfonamide platform to biaryl sulfone platform retains the 5-HT6.R affinity when tested in vitro in cell based reporter gene functional assay.