4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone

Base Information

• Chemical Name: 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone
• CAS No.: 51787-84-9
• Molecular Formula: C₁₇H₂₂FNO₃
• Molecular Weight: 307.365
• Mol file: 51787-84-9.mol

Synonyms:4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone

Chemical Property of 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone

There total 7 articles about 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4,4-ethylenedioxy-piperidine (177-11-7) + 4-(4-fluorophenyl)-4-oxo-n-butyl chloride (3874-54-2,41167-07-1) → 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone (51787-84-9)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; for 16h; Heating;

DOI:10.1055/s-1993-25946

Reference yield: 45.0%

4,4-ethylenedioxy-piperidine (177-11-7) + 1-(4-fluorophenyl)-4-bromo-1-butanone (40132-01-2) → 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone (51787-84-9)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; for 4h; Reflux;

DOI:10.1021/acs.jmedchem.5b00593

Reference yield:

1-benzyl-4-piperidone hydrochloride (20821-52-7) → 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone (51787-84-9)

Guidance literature:

Multi-step reaction with 4 steps

1: benzene / Heating

2: benzene / Heating

3: KOH / ethanol / Heating

4: K₂CO₃

With potassium hydroxide; potassium carbonate; In ethanol; benzene;

DOI:10.1135/cccc19733879

upstream raw materials:

4,4-ethylenedioxy-piperidine

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

8-Methyl-1,4-dioxa-8-azoniaspiro<4.5>decan

1-benzyl-4-piperidone hydrochloride

Downstream raw materials:

1-<4,4-ethylenedithio-4-(4-fluorophenyl)butyl>-4-piperidinone

1-(4-Fluoro-phenyl)-4-{4-[(2-nitro-4-trifluoromethyl-phenyl)-hydrazono]-piperidin-1-yl}-butan-1-one

1-(4-Fluoro-phenyl)-4-{4-[(4-methoxy-2-nitro-phenyl)-hydrazono]-piperidin-1-yl}-butan-1-one

1-(4-Fluoro-phenyl)-4-{4-[(5-methoxy-2-nitro-phenyl)-hydrazono]-piperidin-1-yl}-butan-1-one