40132-01-2

Basic information

• Product Name: 4-broMo-1-(4-fluorophenyl)butan-1-one
• Synonyms: 4-broMo-1-(4-fluorophenyl)butan-1-one;4-broMo-1-(4-fluorophenyl)-1-butanone;1-Butanone, 4-bromo-1-(4-fluorophenyl)-;4-Bromo-1-(4-fluorophenyl)
• CAS NO: 40132-01-2
• Molecular Formula: C₁₀H₁₀BrFO
• Molecular Weight: 245.0882032
• Mol File: 40132-01-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-broMo-1-(4-fluorophenyl)butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-1-(4-fluorophenyl)butan-1-one(40132-01-2)
• EPA Substance Registry System: 4-broMo-1-(4-fluorophenyl)butan-1-one(40132-01-2)

Safety Data

• Hazardous Substances Data: 40132-01-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research:
4-bromo-1-(4-fluorophenyl)butan-1-one is used as a research chemical for studying its properties and potential applications in various chemical reactions and processes. Its unique structure and reactivity make it a valuable compound for scientific investigations.
Used in Pharmaceutical Industry:
4-bromo-1-(4-fluorophenyl)butan-1-one is used as an intermediate in the synthesis of pharmaceutical compounds. Its specific functional groups and structural features can be utilized in the development of new drugs with potential therapeutic benefits.
Used in Material Science:
4-bromo-1-(4-fluorophenyl)butan-1-one can be used as a building block in the development of new materials with specific properties. Its aromatic and halogenated nature may contribute to the creation of materials with unique characteristics for various applications.
Used in Organic Synthesis:
4-bromo-1-(4-fluorophenyl)butan-1-one serves as a key intermediate in organic synthesis, allowing chemists to create a variety of complex organic molecules. Its reactivity and structural features make it a versatile compound for constructing diverse organic compounds.

Upstream product

• 130387-74-5 4-fluorophenylmagnesium chloride 
• 89326-70-5 1-bromo-4-(4-fluorophenyl)-butane 
• 339365-53-6 1-(4-fluorophenyl)cyclobutan-1-ol 
• 462-06-6 fluorobenzene 
• 927-58-2 4-bromobutyroyl chloride 

Downstream Products

• 2856-81-7 1-(4-fluoro-phenyl)-4-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-butan-1-one 
• 88327-90-6 2-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-hexahydro-pyrido[1,2-a]pyrazin-1-one 
• 79108-56-8 1-(4-Fluoro-phenyl)-4-(7-methyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-butan-1-one 
• 24678-13-5 lenperone 
• 60390-52-5 1-(4-Fluoro-phenyl)-4-(octahydro-pyrazino[1,2-a]azepin-2-yl)-butan-1-one 
• 23484-92-6 8-[4-(4-fluoro-phenyl)-4-oxo-butyl]-4-phenyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one 
• 23484-75-5 4-ethyl-8-[4-(4-fluoro-phenyl)-4-oxo-butyl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one 
• 40131-80-4 8-[4-(4-fluoro-phenyl)-4-oxo-butyl]-4-methyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one 
• 1467720-34-8 1-(4-fluorophenyl)-4-(vinylthio)butan-1-ol 
• 1467720-28-0 1-(4-fluorophenyl)-4-mercaptobutan-1-ol 
• 1467720-22-4 C₁₀H₁₂BrFO 
• 143790-25-4 1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-piperidine-3-carboxylic acid 
• 58038-77-0 4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one 

Relevant articles and documents

Transition-Metal-Free Ring-Opening Reaction of 2-Halocyclobutanols through Ring Contraction

The present work describes the preparation of halohydrins from 2-halocyclobutanones by means of reactions with Grignard reagents at ?78 °C. We discovered that the prepared cyclobutanols underwent a thermal ring-opening reaction. Depending on the structure of the starting cyclobutanol, different products were formed. More specifically, 1-substituted 2-bromocyclobutan-1-ol was found to open to γ-substituted butyrophenones. A novel 1,3-dihydro-2H-inden-2-ylidene derivative was obtained for indene-derived cyclobutanols. Based on the outcomes of the performed experiments, a mechanism for the ring-opening of cyclobutanols can be proposed.

Intramolecular Cyclization of Brominated Oxime Ether Promoted with Ytterbium(0) to the Synthesis of Cyclic Imines

The first utility of ytterbium(0) as a mediating-metal in the intramolecular cyclization of brominated oxime ether was reported in this paper. In contrast to the prior methods, the N–O bond was used as a receptor of nucleophilic reagent, rather than as a source of N-centered radicals. Cyclic imines were obtained in this one-pot reaction with a broad scope of substrates and feasible reaction conditions.

Light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds

Visible light-induced organic reactions are important chemical transformations in organic chemistry, and their efficiency highly depends on suitable photocatalysts. However, the commonly used photocatalysts are precious transition-metal complexes and elaborate organic dyes, which hamper large-scale production due to high cost. Here, for the first time, we report a novel strategy: light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds, allowing high-value-added aromatic ketones and carboxylic acids to be easily prepared in high-to-excellent yields using readily available alkyl arenes, methyl arenes and aldehydes as materials. The mechanistic investigations showed that the treatment of inexpensive and readily available sodium trifluoromethanesulfinate with oxygen under irradiation of light could in situ form a pentacoordinate sulfide intermediate as an efficient photosensitizer. The method represents a highly efficient, economical and environmentally friendly strategy, and the light and oxygen-enabled sodium trifluoromethanesulfinate photocatalytic system represents a breakthrough in photochemistry. This journal is

Iminyl Radicals by Reductive Cleavage of N-O Bond in Oxime Ether Promoted by SmI2: A Straightforward Synthesis of Five-Membered Cyclic Imines

A new generation method of N-centered radicals from the reductive cleavage of the N-O bond in oxime ether promoted by SmI2 is reported for the first time. The in-situ-generated N-centered radicals underwent intramolecular cyclization to afford five-membered cyclic imines in two manners: N-centered radical addition and N-centered anion nucleophilic substitution. From a synthetic point of view, an efficient synthetic method of five-membered cyclic imines was developed. A mechanism of the transformation was proposed.

Visible-light-enhanced ring opening of cycloalkanols enabled by br?nsted base-tethered acyloxy radical induced hydrogen atom transfer-electron transfer

A metal-free ring opening/halogenation of cycloalkanols, which combines both PPO/TBAX oxidant system and blue LEDs irradiation, is presented. This method produces diverse γ, α, and even more remotely halogenated ketones in moderate to excellent yields under mild conditions. Interestingly, experimental and computational studies demonstrate the novel ring size-dependent concerted/stepwise (four-/five- to eight-membered rings) hydrogen atom transfer-electron transfer induced by Br?nsted base-tethered acyloxy radical, which indicates distinct advantages brought by the cyclic structure of diacyl peroxides.

Novel compound capable of activating Nrf2, and pharmaceutical compositions comprising the same

The present invention provides a novel compound which can activate Nrf2 that is a transcription factor for expression of the quinone reductase gene. Therefore the compound is effective for inhibiting apoptosis and preventing and treating brain nerve disea

Synthesis and Nrf2 activating ability of thiourea and vinyl sulfoxide derivatives

Thiourea and vinyl sulfoxide derivatives were designed based on the structures of sulforaphane and gallic acid, prepared and tested for HO-1 inducing activity as a measure of Nrf2 activation, and inhibitory effect on NO production as a measure of anti-inf

Synthesis of γ-halogenated ketones via the Ce(IV)-mediated oxidative coupling of cyclobutanols and inorganic halides

A straightforward method for the synthesis of γ-halo-substituted ketones formed via the CAN-initiated oxidative addition of halides to 1-substituted cyclobutanols has been developed. This method has short reaction times, and provides access to a range of bromo and iodo γ-substituted ketones in good to excellent yields.

9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones

Compounds useful in the prevention and/or treatment of hypertension, congestive heart failure, arrhythmia, migraine, vasospastic disorders, and asthma are represented by the formula STR1 wherein: R1 is STR2 wherein X is hydrogen, lower alkyl, lower alkoxy, halo, carboxamido or hydroxy; m is 1, 2 or 3; and n is 1, 2 or 3; R2, R3 and R4 are independently hydrogen or lower alkyl; and the pharmaceutically acceptable acid addition salts thereof.