(6S)-2-nitro-6-({4-[4-(trifluoromethoxy)benzyl]-benzyl}oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Base Information

Chemical Name:(6S)-2-nitro-6-({4-[4-(trifluoromethoxy)benzyl]-benzyl}oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
CAS No.:1263417-10-2
Molecular Formula:C₂₁H₁₈F₃N₃O₅
Molecular Weight:449.386
Hs Code.:

Synonyms:(6S)-2-nitro-6-({4-[4-(trifluoromethoxy)benzyl]-benzyl}oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

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Chemical Property of (6S)-2-nitro-6-({4-[4-(trifluoromethoxy)benzyl]-benzyl}oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

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Technology Process of (6S)-2-nitro-6-({4-[4-(trifluoromethoxy)benzyl]-benzyl}oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

There total 5 articles about (6S)-2-nitro-6-({4-[4-(trifluoromethoxy)benzyl]-benzyl}oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 187235-08-1
(S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol

: 1263417-31-7
1-(bromomethyl)-4-[4-(trifluoromethoxy)benzyl]-benzene

: 1263417-10-2
(6S)-2-nitro-6-({4-[4-(trifluoromethoxy)benzyl]-benzyl}oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h;

Reference yield:

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1263417-10-2
(6S)-2-nitro-6-({4-[4-(trifluoromethoxy)benzyl]-benzyl}oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 24 h / 105 °C / Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether / 3 h / 20 °C

3: phosphorus tribromide / dichloromethane / 2 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C

With lithium aluminium tetrahydride; phosphorus tribromide; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 1263417-10-2
(6S)-2-nitro-6-({4-[4-(trifluoromethoxy)benzyl]-benzyl}oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 24 h / 105 °C / Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether / 3 h / 20 °C

3: phosphorus tribromide / dichloromethane / 2 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C

With lithium aluminium tetrahydride; phosphorus tribromide; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;