[2-hydroxy-3-tritio-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine

Base Information

• Chemical Name: [2-hydroxy-3-tritio-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine
• CAS No.: 757975-09-0
• Molecular Formula: C₂₅H₂₉F₃N₆O₃
• Molecular Weight: 520.531

Synonyms:[2-hydroxy-3-tritio-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine

Chemical Property of [2-hydroxy-3-tritio-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine

Chemical Property:

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Technology Process of [2-hydroxy-3-tritio-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine

There total 2 articles about [2-hydroxy-3-tritio-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-hydroxy-3-iodo-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine (757975-05-6) → [2-hydroxy-3-tritio-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine (757975-09-0)

Guidance literature:

With tritium; triethylamine; palladium on activated charcoal; In N,N-dimethyl-formamide; at 20 ℃; for 1h; atmospheric pressure;

DOI:10.1002/jlcr.802

Reference yield:

(2S,3S)-1-t-butoxycarbonyl-2-phenyl-3-[2-hydroxy-5-(5'-trifluoromethyl-tetrazol-1-yl)phenylmethyleneamino]piperidine (262598-92-5) → [2-hydroxy-3-tritio-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine (757975-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1: IPy₂BF₄ / CH₂Cl₂ / 1 h / 20 °C

2: tritium; triethylamine / palladium on carbon / dimethylformamide / 1 h / 20 °C / atmospheric pressure

With tritium; Barluenga reagent; triethylamine; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.802

Reference yield:

[2-hydroxy-3-tritio-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine (757975-09-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/jlcr.802

upstream raw materials:

[2-hydroxy-3-iodo-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-([2S,3S]-1-t-butoxycarbonyl-2-phenyl-piperidin-3-yl)-amine

(2S,3S)-1-t-butoxycarbonyl-2-phenyl-3-[2-hydroxy-5-(5'-trifluoromethyl-tetrazol-1-yl)phenylmethyleneamino]piperidine

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