Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine

Base Information

Chemical Name:Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine
CAS No.:136235-07-9
Molecular Formula:C₁₉H₂₇NO₇S
Molecular Weight:413.492
Hs Code.:

Synonyms:Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine

Suppliers and Price of Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine

There total 6 articles about Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 136175-14-9
(2R,5R)-5-Hydroxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 136235-07-9
Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine

Guidance literature:: With pyridine; at 0 ℃; for 18h;
DOI:10.1021/jo00023a037

Reference yield:

: 90290-04-3,50990-24-4,17740-40-8,52321-06-9,90365-12-1
trans-N-benzyl-2,5-bis(ethoxycarbonyl)pyrrolidine

: 136235-07-9
Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / H₂ / Pd-C / ethanol / 18 h / 40 °C / 2585.7 Torr

2: 90 percent / acetonitrile / 60 h / 25 °C

3: 74 percent / 1.0 M aq. NaOH / ethanol / 72 h / 23 °C

4: 1) LiBH₄ / 1) THF, a) 0 deg C, 1 h, b) 23 deg C, 12 h, 2) ether

5: 89 percent / pyridine / 18 h / 0 °C

With pyridine; sodium hydroxide; lithium borohydride; hydrogen; palladium on activated charcoal; In ethanol; acetonitrile;
DOI:10.1021/jo00023a037

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 136235-07-9
Racemic trans-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-5-<(tosyloxy)methyl>pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / acetonitrile / 60 h / 25 °C

2: 74 percent / 1.0 M aq. NaOH / ethanol / 72 h / 23 °C

3: 1) LiBH₄ / 1) THF, a) 0 deg C, 1 h, b) 23 deg C, 12 h, 2) ether

4: 89 percent / pyridine / 18 h / 0 °C

With pyridine; sodium hydroxide; lithium borohydride; In ethanol; acetonitrile;
DOI:10.1021/jo00023a037