CAMPTOTHECIN, [(G)3H]

Base Information

• Chemical Name: CAMPTOTHECIN, [(G)3H]
• CAS No.: 91926-09-9
• Molecular Formula: C₂₀H₁₆N₂O₄
• Molecular Weight: 348.358
• Mol file: 91926-09-9.mol

Synonyms:1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4-hydroxy-, labeled with tritium, (S)-; Camptothecin labeled withtritium

Chemical Property of CAMPTOTHECIN, [(G)3H]

Chemical Property:

• PSA: 81.42000
• LogP: 2.07960

Purity/Quality:

99% ^*data from raw suppliers

CAMPTOTHECIN-[12-3H] 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CAMPTOTHECIN, [(G)3H]

There total 420 articles about CAMPTOTHECIN, [(G)3H] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

(E)-N-(2-aminobenzylidene)-4-methylaniline (55857-35-7) + (4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione (110351-94-5) → camptothecin (7689-03-4,91926-09-9)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating; 1) 30 min, 2) 3 h;

Reference yield: 83.0%

4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one (841276-70-8) → camptothecin (7689-03-4,91926-09-9)

Guidance literature:

4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one; With potassium osmate; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; at 0 ℃;

With iodine; calcium carbonate; In methanol; water; at 40 ℃;

DOI:10.1002/asia.201403190

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 7-((2R,4S)-2-tert-butyl-4-ethyl-5-oxo-1,3-dioxolan-4-yl)indolizino[1,2-b]quinolin-9(11H)-one → camptothecin (7689-03-4,91926-09-9)

Guidance literature:

With hydrogenchloride; acetic acid; In 1,4-dioxane; water; at 90 ℃; for 19h;

DOI:10.1016/j.tet.2019.03.028

upstream raw materials:

3-ethyl-1,13-dioxo-3a,4,4a,11,13,13a-hexahydro-1H,3H-furo[3',4':6,7]indolizino[1,2-b]quinoline-3-carboxylic acid amide

4-ethyl-6-formyl-1,5b,6,11,11a,12-hexahydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione

4-ethyl-1,12-dihydro-14-H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione

formaldehyd

Downstream raw materials:

(S)-7-methylcamptothecin

(R)-(-)-20-fluorocamptothecin

(S)-(+)-20-fluorocamptothecin

9-amino-20(S)-camptothecin