(2S,4R)-2-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Base Information

Chemical Name:(2S,4R)-2-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide
CAS No.:175979-71-2
Molecular Formula:C₂₈H₄₃NO₄Si
Molecular Weight:485.739
Hs Code.:

Synonyms:(2S,4R)-2-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

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Chemical Property of (2S,4R)-2-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

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Technology Process of (2S,4R)-2-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

There total 2 articles about (2S,4R)-2-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14980-86-0,42407-58-9
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-3-phenylpropanamide

: 124150-87-4
tert-butyldimethylsilyl (R)-glycidyl ether

: 175979-71-2
(2S,4R)-2-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: With tert-butyldimethylsilyl (R)-glycidyl ether; lithium chloride; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 -> 23 deg C, 2.) THF, -5 deg C, 11 h;
DOI:10.1021/jo952032o

Reference yield:

: 114413-26-2,123237-62-7,124150-87-4,78906-15-7
tert-butyldimethylsilyl glycidyl ether

: 14980-86-0,42407-58-9
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-3-phenylpropanamide

: 175979-71-2
(2S,4R)-2-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

: (2S,4S)-2-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

: (2R,4S)-2-Benzyl-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: With lithium chloride; lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, -78 -> 23 deg C, 2.) THF, 0 deg C;
DOI:10.1021/jo952032o