2-Hydroxy-4-methylpyridine

Base Information

• Chemical Name: 2-Hydroxy-4-methylpyridine
• CAS No.: 91914-05-5
• Molecular Formula: C₆H₇NO
• Molecular Weight: 109.128
• European Community (EC) Number: 627-289-1
• NSC Number: 523149,132870
• UNII: JE7V4GNL8Z
• DSSTox Substance ID: DTXSID00299790
• Nikkaji Number: J110.368G
• Wikidata: Q70000102
• ChEMBL ID: CHEMBL4593828
• Mol file: 91914-05-5.mol

Synonyms:2-Hydroxy-4-methylpyridine;13466-41-6;4-methylpyridin-2-ol;4-methyl-1H-pyridin-2-one;4-Methyl-2(1H)-pyridinone;2(1H)-Pyridinone, 4-methyl-;4-methylpyridin-2(1H)-one;4-methyl-1,2-dihydropyridin-2-one;4-Methyl-2-pyridone;91914-05-5;4-Methyl-2-pyridinol;2(1H)-Pyridone, 4-methyl-;MFCD00134298;JE7V4GNL8Z;NSC-132870;NSC-523149;2-Hydroxy-4-picoline;MFCD00030766;4-Methyl-2-pyridinone;4-Methylpyridin-2-one;4-Methyl-2[1H]-pyridone;4-Methyl-2-(1H)-pyridinone;2-Hydroxy-4-methyl pyridine;4-METHYL-2(1H)-PYRIDONE;4-methyl-pyridin-2-ol;2-hydroxy-4-methyl pyridine;NSC132870;Cc1ccnc(O)c1;Hydroxy-4-methylpyridine;2-Pyridinol,4-methyl-;UNII-JE7V4GNL8Z;2-hydroxy-4methylpyridine;4-methy-2(1H)-pyridone;2-hydroxy-4-methyl-pyridine;SCHEMBL245430;SCHEMBL8747034;CHEMBL4593828;DTXSID00299790;CHEBI:194825;2-Hydroxy-4-methylpyridine, 99%;BBL102829;NSC523149;STL556637;AKOS006227963;AKOS015842412;AB03735;AC-5128;CS-W017769;AM803166;AS-14953;BP-12688;SY021568;A2865;FT-0612548;FT-0691706;H1052;EN300-66899;AE-646/31212037;J-006588;J-400628;J-515811;F8880-7854;Z1065655286;CQJ

Chemical Property of 2-Hydroxy-4-methylpyridine

Chemical Property:

• Melting Point: 128-133℃
• Boiling Point: 186℃(12 torr)
• PKA: 10.62±0.10(Predicted)
• PSA: 50.72000
• Density: 1.120±0.06 g/cm3(Predicted)
• LogP: 4.90920
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 109.052763847
• Heavy Atom Count: 8
• Complexity: 167

Purity/Quality:

99% ^*data from raw suppliers

4-Methylpyridin-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S37/39:

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)NC=C1

Technology Process of 2-Hydroxy-4-methylpyridine

There total 4 articles about 2-Hydroxy-4-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-Amino-4-methylpyridine (695-34-1) → 2-hydroksy-4-methyl-pyridine (13466-41-6,91914-05-5)

Guidance literature:

2-Amino-4-methylpyridine; With sulfuric acid; sodium nitrite; In water; at 0 - 95 ℃; for 2.25h;

With sodium hydroxide; In water; at 20 ℃; pH=6 - 7;

Reference yield: 67.0%

2-methoxy-4-methyl-pyridine (100848-70-2) → 2-hydroksy-4-methyl-pyridine (13466-41-6,91914-05-5)

Guidance literature:

With L-Selectride; In tetrahydrofuran; for 9h; chemoselective reaction; Reflux; Inert atmosphere;

DOI:10.1055/s-0037-1612427

Reference yield: 64.0%

→ 2-hydroksy-4-methyl-pyridine (13466-41-6,91914-05-5) + 3-methylpyridin-2-ol (1003-56-1,91914-04-4)

Guidance literature:

upstream raw materials:

2-Amino-4-methylpyridine

picoline

2-methoxy-4-methyl-pyridine

Downstream raw materials:

ethyl 2-[(4-methylpyridin-2-yl)oxy]acetate