4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzoyl chloride

Base Information

Chemical Name:4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzoyl chloride
CAS No.:1246433-80-6
Molecular Formula:C₂₂H₁₂ClFN₄O
Molecular Weight:402.815
Hs Code.:

Synonyms:4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzoyl chloride

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Chemical Property of 4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzoyl chloride

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Technology Process of 4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzoyl chloride

There total 6 articles about 4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246433-63-5
4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-benzoic acid

: 1246433-80-6
4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzoyl chloride

Guidance literature:: With thionyl chloride; at 70 ℃; for 20h;

Reference yield:

: 1201786-84-6
3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1246433-80-6
4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzoyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

2.2: 1 h

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 120 °C / sealed tube; Microwave irradiation

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

5.1: thionyl chloride / 20 h / 70 °C

With n-butyllithium; thionyl chloride; water; sodium hydride; caesium carbonate; diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1201787-19-0
3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo-[2,3-b:5,4-c']dipyridine

: 1246433-80-6
4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzoyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

1.2: 1 h

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 120 °C / sealed tube; Microwave irradiation

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

4.1: thionyl chloride / 20 h / 70 °C

With n-butyllithium; thionyl chloride; water; caesium carbonate; diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;