3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

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Chemical Name:3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine
CAS No.:1201787-20-3
Molecular Formula:C₂₂H₁₄FIN₄O₂S
Molecular Weight:544.348
Hs Code.:

Synonyms:3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

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Chemical Property of 3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

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Technology Process of 3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

There total 4 articles about 3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1201787-19-0
3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo-[2,3-b:5,4-c']dipyridine

: 1201787-20-3
3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

Guidance literature:: 3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo-[2,3-b:5,4-c']dipyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

With iodine; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

Reference yield:

: 5'-chloro-5-fluoro-3,2':4',3-terpyridin-2-amine

: 1201787-20-3
3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / palladium diacetate; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene / 1,4-dioxane / 18 h / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C

3.2: 1 h

With n-butyllithium; potassium tert-butylate; sodium hydride; diisopropylamine; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1201787-20-3
3-fluoro-4-iodo-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C

With n-butyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;