2-Morpholinoacetic acid hydrochloride

Base Information

Chemical Name:2-Morpholinoacetic acid hydrochloride
CAS No.:89531-58-8
Molecular Formula:C6H12ClNO3
Molecular Weight:181.619
Hs Code.:29349990
European Community (EC) Number:675-845-7
ChEMBL ID:CHEMBL4630647
DSSTox Substance ID:DTXSID40590793
Mol file:89531-58-8.mol

Synonyms:89531-58-8;2-Morpholinoacetic acid hydrochloride;Morpholin-4-yl-acetic acid hydrochloride;4-morpholineacetic acid hydrochloride;Morpholin-4-ylacetic acid hydrochloride;4-Morpholinacetic acid HCl;2-(morpholin-4-yl)acetic acid hydrochloride;4-Morpholineacetic acid, HCl;2-morpholin-4-ylacetic acid;hydrochloride;4-morpholinylacetic acid hydrochloride;2-morpholinoaceticacidhydrochloride;MFCD03540888;4-Morpholineacetic acid, hydrochloride;4-Morpholineaceticacid, hydrochloride;(morpholin-4-yl)acetic acid hydrochloride;Morpholin-4-ylacetic acid HCl;SCHEMBL1128463;CHEMBL4630647;DTXSID40590793;ICGYBJNONRDZOP-UHFFFAOYSA-N;4-Morpholinylacetic acid HCl salt;Morpholinoacetic Acid Hydrochloride;AMY23804;BCP10116;CS-M2890;AKOS005144470;PS-8530;4-Morpholineacetic acid, (hydrochloride);2-morpholin-4-ylacetic acid hydrochloride;2-morpholinoacetic acid hydrochloride salt;AC-30174;SY032269;M2608;EN300-41518;morpholin-4-yl-acetic acid mono-hydrochloride;2-Morpholinoacetic acid hydrochloride, AldrichCPR;J-515838;Morpholin-4-yl-acetic acid hydrochloride, AldrichCPR;(Morpholin-4-yl)acetic acid--hydrogen chloride (1/1);2-(4-Fluoro-2-hydroxyphenyl)isonicotinic acid (~90%);F2130-0038;Z1270246390

Suppliers and Price of 2-Morpholinoacetic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-MorpholineaceticAcidHydrochloride
250mg
$ 70.00

TRC
4-MorpholineaceticAcidHydrochloride
10g
$ 445.00

TCI Chemical
Morpholinoacetic Acid Hydrochloride >98.0%(T)
5g
$ 135.00

TCI Chemical
Morpholinoacetic Acid Hydrochloride >98.0%(T)
1g
$ 42.00

SynQuest Laboratories
Morpholin-4-ylacetic acid hydrochloride
10 g
$ 80.00

SynQuest Laboratories
Morpholin-4-ylacetic acid hydrochloride
1 g
$ 16.00

SynQuest Laboratories
Morpholin-4-ylacetic acid hydrochloride
5 g
$ 42.00

Sigma-Aldrich
Morpholin-4-yl-acetic acid hydrochloride Aldrich
500mg
$ 129.00

Matrix Scientific
Morpholin-4-yl-acetic acid hydrochloride 97%
5g
$ 39.00

Matrix Scientific
Morpholin-4-yl-acetic acid hydrochloride 97%
25g
$ 118.00

Total 75 raw suppliers

Chemical Property of 2-Morpholinoacetic acid hydrochloride

Chemical Property:

Appearance/Colour:White solid
Melting Point:160-161℃
Boiling Point:271.9oC at 760 mmHg
Flash Point:118.2oC
PSA：49.77000
Density:1.202 g/cm3
LogP:-0.65890
Storage Temp.:Inert atmosphere,Room Temperature
Water Solubility.:Insoluble in water.
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:181.0505709
Heavy Atom Count:11
Complexity:120

Purity/Quality:

99%, ^*data from raw suppliers

4-MorpholineaceticAcidHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36-36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1CC(=O)O.Cl
Uses 4-Morpholineacetic Acid Hydrochloride is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

Technology Process of 2-Morpholinoacetic acid hydrochloride

There total 5 articles about 2-Morpholinoacetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 88217-68-9
(4-morpholinyl)acetic acid 1,1-dimethylethyl ester

: 89531-58-8
N-(carboxymethyl)morpholine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 12h;

Reference yield: 96.0%

: 3235-82-3
N-morpholylacetic acid ethyl ester

: 89531-58-8
N-(carboxymethyl)morpholine hydrochloride

Guidance literature:: With hydrogenchloride; In water; for 16h; Reflux;
DOI:10.1021/jacs.7b05619

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 105-36-2
ethyl bromoacetate

: 89531-58-8
N-(carboxymethyl)morpholine hydrochloride

Guidance literature:: morpholine; ethyl bromoacetate; In diethyl ether; at 20 ℃; for 2h;

With potassium hydroxide; In ethanol; at 20 ℃; for 4h;

With hydrogenchloride; In ethanol;