Androsta-1,4-diene-3-one

Base Information

• Chemical Name: Androsta-1,4-diene-3-one
• CAS No.: 3090-99-1
• Molecular Formula: C₁₉H₂₆O
• Molecular Weight: 270.415
• Mol file: 3090-99-1.mol

Synonyms:3-ketoandrosta-1,4-diene

Chemical Property of Androsta-1,4-diene-3-one

Chemical Property:

• Melting Point: 80-81 °C
• Boiling Point: 392.6±12.0 °C(Predicted)
• Density: 1.07±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Androsta-1,4-diene-3-one

There total 8 articles about Androsta-1,4-diene-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

androstan-3-one (1224-95-9,118371-41-8) → (5S,8S,9S,10S,13S,14S)-10,13-dimethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one (3248-10-0) + 4-androsten-3-one (2872-90-4) + 3-ketoandrosta-1,4-diene (3090-99-1)

Guidance literature:

With toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 96h; Ambient temperature;

DOI:10.1021/jo00245a013

Reference yield:

4-androsten-3-one (2872-90-4) → 3-ketoandrosta-1,4-diene (3090-99-1)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; Heating;

Reference yield:

(5R,8S,9S,10R,13S,14S)-2,4-Dibromo-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one → 3-ketoandrosta-1,4-diene (3090-99-1)

Guidance literature:

With lithium carbonate; lithium bromide; In N,N-dimethyl-formamide; at 100 ℃; Yield given;

DOI:10.1021/jm00123a026

upstream raw materials:

androstan-3-one

4-androsten-3-one

androst-5-en-3β-ol

17-iodo-5,16-androstadien-3-ol

Downstream raw materials:

1.5-Cyclo-10α-androsten-(3)-on-(2)

Refernces

• 1、 Sherwin,McMullan,Covey. "Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogues of androsta-1,4-diene-3,17-dione". . p. 651 - 658. Retrieved 2007/10/02.
• 2、 -. "17-Nor-6-methyl-steroids". . . Retrieved 2008/06/13.