8-bromo-6-phenylimidazo[1,2-b]pyridazine

Base Information

Chemical Name:8-bromo-6-phenylimidazo[1,2-b]pyridazine
CAS No.:1431773-73-7
Molecular Formula:C₁₂H₈BrN₃
Molecular Weight:274.12
Hs Code.:

Synonyms:8-bromo-6-phenylimidazo[1,2-b]pyridazine

Suppliers and Price of 8-bromo-6-phenylimidazo[1,2-b]pyridazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-bromo-6-phenylimidazo[1,2-b]pyridazine

Chemical Property:

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Technology Process of 8-bromo-6-phenylimidazo[1,2-b]pyridazine

There total 3 articles about 8-bromo-6-phenylimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 630416-37-4
4-bromo-6-phenylpyridazin-3-amine

: 621-62-5
chloroacetaldehyde diethyl acetal

: 1431773-73-7
8-bromo-6-phenylimidazo[1,2-b]pyridazine

Guidance literature:: 4-bromo-6-phenylpyridazin-3-amine; chloroacetaldehyde diethyl acetal; With toluene-4-sulfonic acid; In isopropyl alcohol; at 80 ℃; for 40h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 98-80-6
phenylboronic acid

: 1431773-73-7
8-bromo-6-phenylimidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 6 h / 100 °C / Inert atmosphere

2: sodium hydrogencarbonate; bromine / methanol / 16.5 h / 20 °C

3: toluene-4-sulfonic acid / isopropyl alcohol / 40 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; sodium hydrogencarbonate; sodium carbonate; toluene-4-sulfonic acid; XPhos; In 1,4-dioxane; methanol; water; isopropyl alcohol;

Reference yield:

: 14966-91-7
3-amino-6-phenylpyridazine

: 1431773-73-7
8-bromo-6-phenylimidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; bromine / methanol / 16.5 h / 20 °C

2: toluene-4-sulfonic acid / isopropyl alcohol / 40 h / 80 °C

With bromine; sodium hydrogencarbonate; toluene-4-sulfonic acid; In methanol; isopropyl alcohol;