4-[2-bromo-5-(propan-2-yloxy)benzyl]-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]piperidine

Base Information

Chemical Name:4-[2-bromo-5-(propan-2-yloxy)benzyl]-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]piperidine
CAS No.:1021174-67-3
Molecular Formula:C₂₅H₃₁BrClNO₃
Molecular Weight:508.883
Hs Code.:

Synonyms:4-[2-bromo-5-(propan-2-yloxy)benzyl]-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]piperidine

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Chemical Property of 4-[2-bromo-5-(propan-2-yloxy)benzyl]-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]piperidine

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Technology Process of 4-[2-bromo-5-(propan-2-yloxy)benzyl]-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]piperidine

There total 11 articles about 4-[2-bromo-5-(propan-2-yloxy)benzyl]-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 391954-31-7
4-[2-bromo-5-(propan-2-yloxy)benzyl]piperidinehydrochloride

: 2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl 4-methylbenzenesulfonate

: 1021174-67-3
4-[2-bromo-5-(propan-2-yloxy)benzyl]-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]piperidine

Guidance literature:: With potassium carbonate; In acetonitrile; for 24h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2016.10.034

Reference yield:

: 150019-61-7
4-[(3-Methoxyphenyl)methyl]piperidine

: 1021174-67-3
4-[2-bromo-5-(propan-2-yloxy)benzyl]-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]piperidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / chloroform; 1,4-dioxane / 21 h / 20 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 70 °C / Inert atmosphere

6.1: hydrogenchloride / chloroform; 1,4-dioxane / 21 h / 20 °C / Inert atmosphere

7.1: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Reflux

With hydrogenchloride; N-Bromosuccinimide; boron tribromide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2016.10.034

Reference yield:

: 391954-24-8
4-(2-bromo-5-methoxybenzyl)piperidine hydrochloride

: 1021174-67-3
4-[2-bromo-5-(propan-2-yloxy)benzyl]-1-[2-(7-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 70 °C / Inert atmosphere

3.1: hydrogenchloride / chloroform; 1,4-dioxane / 21 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / acetonitrile / 24 h / Inert atmosphere; Reflux

With hydrogenchloride; boron tribromide; potassium carbonate; In 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2016.10.034