Technology Process of 1-[9-(2-benzyl-6-ureidomethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-3-phenyl-urea methylsulfonamide
There total 3 articles about 1-[9-(2-benzyl-6-ureidomethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-3-phenyl-urea methylsulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
dichloromethane;
at 20 ℃;
for 72h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: toluene / 16 h / 25 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h
3: acetic acid / tetrahydrofuran; 1,4-dioxane; water / 24 h / 50 °C
4: trifluoroacetic acid / 7 h / 0 °C / Molecular sieve
5: pyridine / 4 h / 20 °C
6: sodium azide / N,N-dimethyl-formamide / 7 h / 80 °C
7: polystyrene-bound triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C
8: dichloromethane / 72 h / 20 °C
With
pyridine; sodium azide; polystyrene-bound triphenylphosphine; tetrabutyl ammonium fluoride; acetic acid; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: Amberlyst 15H+ resin / N,N-dimethyl-formamide / 3 h / 55 °C
2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 23 °C
3: toluene / 16 h / 25 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h
5: acetic acid / tetrahydrofuran; 1,4-dioxane; water / 24 h / 50 °C
6: trifluoroacetic acid / 7 h / 0 °C / Molecular sieve
7: pyridine / 4 h / 20 °C
8: sodium azide / N,N-dimethyl-formamide / 7 h / 80 °C
9: polystyrene-bound triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C
10: dichloromethane / 72 h / 20 °C
With
pyridine; 1H-imidazole; sodium azide; polystyrene-bound triphenylphosphine; tetrabutyl ammonium fluoride; acetic acid; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
