(2R)-tert-butyl 2-((S)-amino(3-fluoro-4-(trifluoromethyl)phenyl)methyl)pyrolidine-1-carboxylate

Base Information

Chemical Name:(2R)-tert-butyl 2-((S)-amino(3-fluoro-4-(trifluoromethyl)phenyl)methyl)pyrolidine-1-carboxylate
CAS No.:1395078-53-1
Molecular Formula:C₁₇H₂₂F₄N₂O₂
Molecular Weight:362.367
Hs Code.:

Synonyms:(2R)-tert-butyl 2-((S)-amino(3-fluoro-4-(trifluoromethyl)phenyl)methyl)pyrolidine-1-carboxylate

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Chemical Property of (2R)-tert-butyl 2-((S)-amino(3-fluoro-4-(trifluoromethyl)phenyl)methyl)pyrolidine-1-carboxylate

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Technology Process of (2R)-tert-butyl 2-((S)-amino(3-fluoro-4-(trifluoromethyl)phenyl)methyl)pyrolidine-1-carboxylate

There total 5 articles about (2R)-tert-butyl 2-((S)-amino(3-fluoro-4-(trifluoromethyl)phenyl)methyl)pyrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1395078-52-0
C₂₅H₂₄F₄N₂O₄

: 1395078-53-1
(2R)-tert-butyl 2-((S)-amino(3-fluoro-4-(trifluoromethyl)phenyl)methyl)pyrolidine-1-carboxylate

Guidance literature:: With hydrazine hydrate; In tetrahydrofuran; methanol; at 20 ℃; for 48h;

Reference yield:

: 288086-98-6
[tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate]

: 1395078-53-1
(2R)-tert-butyl 2-((S)-amino(3-fluoro-4-(trifluoromethyl)phenyl)methyl)pyrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether / 0.17 h / -78 °C / Inert atmosphere

1.2: 0.17 h / -78 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere; Cooling with ice

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 h / 0 - 20 °C

4.1: hydrazine hydrate / tetrahydrofuran; methanol / 48 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether;

Reference yield:

: 37784-17-1,59433-50-0
N-(tert-butoxycarbonyl)-D-proline

: 1395078-53-1
(2R)-tert-butyl 2-((S)-amino(3-fluoro-4-(trifluoromethyl)phenyl)methyl)pyrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / dichloromethane / 0.25 h / -15 °C / Inert atmosphere

1.2: 18 h / 20 °C

2.1: n-butyllithium / diethyl ether / 0.17 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere; Cooling with ice

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 h / 0 - 20 °C

5.1: hydrazine hydrate / tetrahydrofuran; methanol / 48 h / 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; n-butyllithium; chloroformic acid ethyl ester; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;