ethyl 5-(4-chlorophenyl)-4-cyclopropyl-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: ethyl 5-(4-chlorophenyl)-4-cyclopropyl-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate
• CAS No.: 1016557-48-4
• Molecular Formula: C₂₁H₁₇Cl₃N₂O₂
• Molecular Weight: 435.737

Synonyms:ethyl 5-(4-chlorophenyl)-4-cyclopropyl-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate

Chemical Property of ethyl 5-(4-chlorophenyl)-4-cyclopropyl-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate

Chemical Property:

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Technology Process of ethyl 5-(4-chlorophenyl)-4-cyclopropyl-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate

There total 2 articles about ethyl 5-(4-chlorophenyl)-4-cyclopropyl-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

1-(2,4-dichlorophenyl)-4-bromo-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (501426-57-9) → ethyl 5-(4-chlorophenyl)-4-cyclopropyl-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate (1016557-48-4)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 140 ℃; Microwave irradiation;

Reference yield: 44.0%

1-(2,4-dichlorophenyl)-4-bromo-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (501426-57-9) + cyclopropylboronic acid (411235-57-9) → ethyl 5-(4-chlorophenyl)-4-cyclopropyl-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate (1016557-48-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; at 140 ℃; Microwave irradiation;

DOI:10.1021/jm800843r

Reference yield:

ethyl 5-(4-chlorophenyl)-4-cyclopropyl-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate (1016557-48-4) → C19H15Cl3N4O

Guidance literature:

With hydrazine; In ethanol; Reflux;

DOI:10.1021/jm800843r

upstream raw materials:

1-(2,4-dichlorophenyl)-4-bromo-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

cyclopropylboronic acid

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