1-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-2,2,2-trifluoro-ethanone

Base Information

• Chemical Name: 1-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-2,2,2-trifluoro-ethanone
• CAS No.: 1080014-49-8
• Molecular Formula: C₁₅H₅Cl₂F₆NOS
• Molecular Weight: 432.173
• Mol file: 1080014-49-8.mol

Synonyms:1-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-2,2,2-trifluoro-ethanone

Chemical Property of 1-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-2,2,2-trifluoro-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-2,2,2-trifluoro-ethanone

There total 2 articles about 1-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-2,2,2-trifluoro-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-trifluoro-1-(6H-thieno[2,3-b]pyrrol-4-yl)-ethanone (1080014-48-7) + 1,3-dichloro-2-fluoro-5-(trifluoromethyl)benzene (77227-81-7) → 1-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-2,2,2-trifluoro-ethanone (1080014-49-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 24h;

Reference yield:

6H-thieno[2,3-b]pyrrole (250-79-3) → 1-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-2,2,2-trifluoro-ethanone (1080014-49-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 18 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 90 °C

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

1-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-2,2,2-trifluoro-ethanone (1080014-49-8) + methylmagnesium bromide (75-16-1) → 2-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-1,1,1-trifluoro-propan-2-ol (1080013-04-2)

Guidance literature:

1-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-2,2,2-trifluoro-ethanone; methylmagnesium bromide; In diethyl ether; at 0 - 20 ℃; for 2h;

With water; ammonium chloride; In diethyl ether; at 20 ℃;

upstream raw materials:

2,2,2-trifluoro-1-(6H-thieno[2,3-b]pyrrol-4-yl)-ethanone

1,3-dichloro-2-fluoro-5-(trifluoromethyl)benzene

6H-thieno[2,3-b]pyrrole

Downstream raw materials:

2-[6-(2,6-dichloro-4-trifluoromethyl-phenyl)-6H-thieno[2,3-b]pyrrol-4-yl]-1,1,1-trifluoro-propan-2-ol