dibenzyl (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl phosphate

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Chemical Name:dibenzyl (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl phosphate
CAS No.:1311319-06-8
Molecular Formula:C₃₅H₃₅F₃N₃O₆PS
Molecular Weight:713.714
Hs Code.:

Synonyms:dibenzyl (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl phosphate

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Chemical Property of dibenzyl (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl phosphate

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Technology Process of dibenzyl (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl phosphate

There total 5 articles about dibenzyl (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1231955-18-2
N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1311319-06-8
dibenzyl (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl phosphate

Guidance literature:: N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In tetrahydrofuran; acetonitrile; at 20 ℃;

With tert.-butylhydroperoxide; In tetrahydrofuran; decane; acetonitrile; at 20 ℃; for 4h;

Reference yield:

: 1232169-35-5,1311319-13-7
2-fluoro-N-(thiazolo[4,5-c]pyridin-2-yl)-5-(trifluoromethyl)benzamide

: 1311319-06-8
dibenzyl (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; tetra-(n-butyl)ammonium iodide; tetraethylammonium iodide / toluene / 12 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

2.2: 4 h / 20 °C

3.1: 1H-tetrazole / acetonitrile; tetrahydrofuran / 20 °C

3.2: 4 h / 20 °C

With 1H-tetrazole; tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; In tetrahydrofuran; toluene; acetonitrile;

Reference yield:

: 89786-54-9
thiazolo[4,5-c]pyridine-2-ylamine

: 1311319-06-8
dibenzyl (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 12 h / 20 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; tetra-(n-butyl)ammonium iodide; tetraethylammonium iodide / toluene / 12 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

3.2: 4 h / 20 °C

4.1: 1H-tetrazole / acetonitrile; tetrahydrofuran / 20 °C

4.2: 4 h / 20 °C

With 1H-tetrazole; tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; ethyl acetate; toluene; acetonitrile;