(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl dihydrogen phosphate

Base Information

Chemical Name:(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl dihydrogen phosphate
CAS No.:1311318-88-3
Molecular Formula:C₂₁H₂₃F₃N₃O₆PS
Molecular Weight:533.465
Hs Code.:

Synonyms:(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl dihydrogen phosphate

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Chemical Property of (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl dihydrogen phosphate

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Technology Process of (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl dihydrogen phosphate

There total 6 articles about (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1311319-06-8
dibenzyl (1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl phosphate

: 1311318-88-3
(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl dihydrogen phosphate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; Inert atmosphere;

Reference yield:

: 89786-54-9
thiazolo[4,5-c]pyridine-2-ylamine

: 1311318-88-3
(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 12 h / 20 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; tetra-(n-butyl)ammonium iodide; tetraethylammonium iodide / toluene / 12 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

3.2: 4 h / 20 °C

4.1: 1H-tetrazole / acetonitrile; tetrahydrofuran / 20 °C

4.2: 4 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C / Inert atmosphere

With 1H-tetrazole; tetraethylammonium iodide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 115029-23-7
2-fluoro-5-(trifluoromethyl)benzoic acid

: 1311318-88-3
(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 12 h / 20 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; tetra-(n-butyl)ammonium iodide; tetraethylammonium iodide / toluene / 12 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

3.2: 4 h / 20 °C

4.1: 1H-tetrazole / acetonitrile; tetrahydrofuran / 20 °C

4.2: 4 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C / Inert atmosphere

With 1H-tetrazole; tetraethylammonium iodide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; toluene; acetonitrile;