6-[(4R,5R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methyl-2-oxo-imidazolidin-4-yl]-hexanoic acid

Base Information

Chemical Name:6-[(4R,5R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methyl-2-oxo-imidazolidin-4-yl]-hexanoic acid
CAS No.:316807-13-3
Molecular Formula:C₁₈H₂₆N₂O₄
Molecular Weight:334.415
Hs Code.:

Synonyms:6-[(4R,5R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methyl-2-oxo-imidazolidin-4-yl]-hexanoic acid

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Chemical Property of 6-[(4R,5R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methyl-2-oxo-imidazolidin-4-yl]-hexanoic acid

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Technology Process of 6-[(4R,5R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methyl-2-oxo-imidazolidin-4-yl]-hexanoic acid

There total 4 articles about 6-[(4R,5R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methyl-2-oxo-imidazolidin-4-yl]-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 316807-12-2
(7R,8R)-7-Amino-8-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-nonanoic acid methyl ester

: 316807-13-3
6-[(4R,5R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methyl-2-oxo-imidazolidin-4-yl]-hexanoic acid

Guidance literature:: With potassium hydroxide; water; In methanol; for 16h; Heating;
DOI:10.1002/1099-0690(200011)2000:21<3575::aid-ejoc3575>3.0.co;2-r

Reference yield:

: 90319-52-1,7480-32-2
(4R)-phenyl-2-oxazolidinone

: 316807-13-3
6-[(4R,5R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methyl-2-oxo-imidazolidin-4-yl]-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / potassium tert-butoxide; 18-crown-6 / tetrahydrofuran / 0.75 h / -78 °C

2: 72 percent / ammonium formate / Pd/C / methanol / 72 h / 20 °C

3: 89 percent / KOH; water / methanol / 16 h / Heating

With potassium hydroxide; 18-crown-6 ether; potassium tert-butylate; water; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; methanol; 1: Addition / 2: Reduction / 3: Hydrolysis;
DOI:10.1002/1099-0690(200011)2000:21<3575::aid-ejoc3575>3.0.co;2-r

Reference yield:

: methyl 7-nitronon-7-enoate

: 316807-13-3
6-[(4R,5R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methyl-2-oxo-imidazolidin-4-yl]-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / potassium tert-butoxide; 18-crown-6 / tetrahydrofuran / 0.75 h / -78 °C

2: 72 percent / ammonium formate / Pd/C / methanol / 72 h / 20 °C

3: 89 percent / KOH; water / methanol / 16 h / Heating

With potassium hydroxide; 18-crown-6 ether; potassium tert-butylate; water; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; methanol; 1: Addition / 2: Reduction / 3: Hydrolysis;
DOI:10.1002/1099-0690(200011)2000:21<3575::aid-ejoc3575>3.0.co;2-r