6-[¹⁸F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester

Base Information

• Chemical Name: 6-[¹⁸F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester
• CAS No.: 1207955-07-4
• Molecular Formula: C₁₂H₄F₅NO₂
• Molecular Weight: 288.163

Synonyms:6-[¹⁸F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester

Chemical Property of 6-[¹⁸F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester

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Technology Process of 6-[¹⁸F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester

There total 16 articles about 6-[¹⁸F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate (1246467-94-6) → 6-[18F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester (1207955-07-4)

Guidance literature:

With K[¹⁸F]F–K₂₂₂ complex; In dimethyl sulfoxide; at 40 ℃; for 0.25h; Temperature;

DOI:10.1039/c9cc09434b

Reference yield: 87.0%

3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-(4-aza-1-azoniabicyclo[2.2.2]octane)trifluoromethanesulfonate → 6-[18F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester (1207955-07-4)

Guidance literature:

With ⁽¹⁸⁾F-fluoride-cryptate complex; In dimethyl sulfoxide; at 40 ℃; for 0.25h; Temperature;

DOI:10.1039/c9cc09434b

Reference yield: 77.6%

[18F]-tetrabutylammonium fluoride (93617-83-5) + N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate (1246467-94-6) → 6-[18F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester (1207955-07-4)

Guidance literature:

With potassium hydrogencarbonate; In acetonitrile; tert-butyl alcohol; at 40 ℃; for 0.166667h;

DOI:10.1021/jm9015813

upstream raw materials:

[18F]-tetrabutylammonium fluoride

N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate

6-chloronicotinic acid 2,3,5,6-tetrafluorophenyl ester

6-hydroxy-3-pyridinecarboxylic acid

Downstream raw materials:

C₅₆H₈₁⁽¹⁸⁾FN₁₆O₁₈S₃

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