N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate

Base Information

• Chemical Name: N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate
• CAS No.: 1246467-94-6
• Molecular Formula: CF₃O₃S*C₁₅H₁₃F₄N₂O₂
• Molecular Weight: 478.344
• Mol file: 1246467-94-6.mol

Synonyms:N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate

Chemical Property of N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate

There total 8 articles about N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trimethylsilyl trifluoromethanesulfonate (27607-77-8) + N,N,N-trimethyl-5-((2,3,5,6-tetrafluorophenoxy)carbonyl)pyridine-2-aminium chloride (1246467-93-5) → N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate (1246467-94-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 93.0%

6-(((trifluoromethyl)sulfonyl)oxy)nicotinic acid 2,3,5,6-tetrafluorophenyl ester + trimethylamine (75-50-3) → N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate (1246467-94-6)

Guidance literature:

In tetrahydrofuran; at 0 ℃;

DOI:10.1039/c9cc09434b

Reference yield: 32.0%

trimethylsilyl trifluoromethanesulfonate (27607-77-8) + 6-chloronicotinic acid 2,3,5,6-tetrafluorophenyl ester (1207954-98-0) + trimethylamine (75-50-3) → N,N,N-trimethyl-3-((2,3,5,6-tetrafluorophenoxy)-carbonyl)pyridin-6-aminium trifluoromethanesulfonate (1246467-94-6)

Guidance literature:

6-chloronicotinic acid 2,3,5,6-tetrafluorophenyl ester; trimethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

trimethylsilyl trifluoromethanesulfonate; In dichloromethane; for 0.0833333h; Inert atmosphere;

DOI:10.1021/jm9015813

upstream raw materials:

trimethylsilyl trifluoromethanesulfonate

6-chloronicotinic acid 2,3,5,6-tetrafluorophenyl ester

trimethylamine

N,N,N-trimethyl-5-((2,3,5,6-tetrafluorophenoxy)carbonyl)pyridine-2-aminium chloride

Downstream raw materials:

6-[¹⁸F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester

6-fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester