[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-oxo-acetic acid ethyl ester

Base Information

• Chemical Name: [tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-oxo-acetic acid ethyl ester
• CAS No.: 216959-44-3
• Molecular Formula: C₁₇H₂₃NO₅
• Molecular Weight: 321.373
• Mol file: 216959-44-3.mol

Synonyms:[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-oxo-acetic acid ethyl ester

Chemical Property of [tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-oxo-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-oxo-acetic acid ethyl ester

There total 2 articles about [tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-oxo-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-Phenylethanol (98-85-1,13323-81-4) + ethyl 2-{[(tert-butoxy)carbonyl]amino}-2-oxoacetate (216959-34-1) → [tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-oxo-acetic acid ethyl ester (216959-44-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 16h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01855-3

Reference yield:

ethoxycarbonylcarbonyl isocyanate (66913-88-0) → [tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-oxo-acetic acid ethyl ester (216959-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 40 °C

2: 72 percent / DEAD, PPh₃ / tetrahydrofuran / 16 h / Ambient temperature

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;

DOI:10.1016/S0040-4039(98)01855-3

Reference yield:

[tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-oxo-acetic acid ethyl ester (216959-44-3) → (R,S)-N-(tert-butyloxycarbonyl)-α-methylbenzylamine (147169-48-0,33036-40-7) + lithium oxalate (553-91-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; for 3h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01855-3

upstream raw materials:

1-Phenylethanol

ethyl 2-{[(tert-butoxy)carbonyl]amino}-2-oxoacetate

ethoxycarbonylcarbonyl isocyanate

Downstream raw materials:

(R,S)-N-(tert-butyloxycarbonyl)-α-methylbenzylamine

lithium oxalate

1-Phenylethylamine oxalamic acid ethyl ester