α-methyl-3-fluorohydrocinnamic acid

Base Information

• Chemical Name: α-methyl-3-fluorohydrocinnamic acid
• CAS No.: 41201-57-4
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.195
• Mol file: 41201-57-4.mol

Synonyms:α-methyl-3-fluorohydrocinnamic acid

Chemical Property of α-methyl-3-fluorohydrocinnamic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-methyl-3-fluorohydrocinnamic acid

There total 3 articles about α-methyl-3-fluorohydrocinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-methyl-3-fluorocinnamic acid → α-methyl-3-fluorohydrocinnamic acid (41201-57-4)

Guidance literature:

In methanol;

Reference yield:

propionic acid (802294-64-0,79-09-4) + 1-(Bromomethyl)-3-fluorobenzene (456-41-7) → α-methyl-3-fluorohydrocinnamic acid (41201-57-4)

Guidance literature:

propionic acid; With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 80 ℃; for 2h; Inert atmosphere;

1-(Bromomethyl)-3-fluorobenzene; In tetrahydrofuran; at 0 - 80 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03794

Reference yield:

3-Fluorobenzaldehyde (456-48-4) → α-methyl-3-fluorohydrocinnamic acid (41201-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; sodium proprionate / propionic acid anhydride

2: methanol

With potassium hydroxide; sodium proprionate; In methanol; propionic acid anhydride;

upstream raw materials:

3-Fluorobenzaldehyde

propionic acid

1-(Bromomethyl)-3-fluorobenzene

Downstream raw materials:

5-Fluoro-2-Methyl-Indan-1-One