2-[[4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenyl]oxy]-2-methylpropanoic acid

Base Information

Chemical Name:2-[[4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenyl]oxy]-2-methylpropanoic acid
CAS No.:1227056-72-5
Molecular Formula:C₂₀H₂₇N₃O₃
Molecular Weight:357.453
Hs Code.:

Synonyms:2-[[4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenyl]oxy]-2-methylpropanoic acid

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Chemical Property of 2-[[4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenyl]oxy]-2-methylpropanoic acid

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Technology Process of 2-[[4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenyl]oxy]-2-methylpropanoic acid

There total 1 articles about 2-[[4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenyl]oxy]-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2052-01-9
2-bromo-2-methylpropionic acid

: 1227056-71-4
4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenol

: 1227056-72-5
2-[[4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenyl]oxy]-2-methylpropanoic acid

Guidance literature:: 4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenol; With sodium hydroxide; In water; butanone; at 43 ℃; for 3h;

2-bromo-2-methylpropionic acid; In water; butanone; at 43 ℃;
DOI:10.1021/jo100562s

Reference yield: 86.0%

: 1227056-72-5
2-[[4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenyl]oxy]-2-methylpropanoic acid

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 2-[[4-[2-[(5-ethyl-2-pyrimidinyl)[[4-[(trifluoromethyl)oxy]phenyl]methyl]amino]-1,1-dimethylethyl]phenyl]oxy]-2-methylpropanoic acid

Guidance literature:: 2-[[4-[2-[(5-ethyl-2-pyrimidinyl)amino]-1,1-dimethylethyl]phenyl]oxy]-2-methylpropanoic acid; With sodium hydride; In tetrahydrofuran; mineral oil; at 40 - 65 ℃; for 1.16667h;

4-trifluoromethoxybenzyl bromide; In tetrahydrofuran; mineral oil; at 65 ℃;
DOI:10.1021/jo100562s