methyl-3-((1S,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)-3-oxopropanoate

Base Information

Chemical Name:methyl-3-((1S,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)-3-oxopropanoate
CAS No.:1623755-30-5
Molecular Formula:C₃₉H₅₂O₆Si
Molecular Weight:644.924
Hs Code.:

Synonyms:methyl-3-((1S,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)-3-oxopropanoate

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Chemical Property of methyl-3-((1S,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)-3-oxopropanoate

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Technology Process of methyl-3-((1S,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)-3-oxopropanoate

There total 11 articles about methyl-3-((1S,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: methyl-3-hydroxy-3-((1S,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)propanoate

: 1623755-30-5
methyl-3-((1S,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)-3-oxopropanoate

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; for 3h; Inert atmosphere; Reflux;
DOI:10.1002/anie.201400617

Reference yield:

: 13259-28-4
bicyiclo<3.2.0>hept-2-en-6-ol

: 1623755-30-5
methyl-3-((1S,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

2.1: potassium dihydrogenphosphate / tert-butyl methyl ether; pentane / 20 °C / pH 7 / Resolution of racemate; Enzymatic reaction

3.1: lithium hydroxide monohydrate / methanol; water / 0.5 h / 20 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5.1: ozone / dichloromethane; methanol / -78 °C

5.2: dehumidified air / 3 h / -78 - 20 °C

6.1: dmap; pyridine / dichloromethane / 2 h / -42 °C / Inert atmosphere

7.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Inert atmosphere; Reflux

8.1: potassium carbonate / dichloromethane; methanol / 1 h / Inert atmosphere

9.1: zinc / tetrahydrofuran / 0.5 h / 40 °C / Inert atmosphere; Reflux

10.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / Inert atmosphere; Reflux

With pyridine; 1H-imidazole; dmap; potassium dihydrogenphosphate; lithium hydroxide monohydrate; potassium carbonate; ozone; zinc; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; N,N-dimethyl-formamide; pentane; 9.1: |Barbier Coupling Reaction;
DOI:10.1002/anie.201400617

Reference yield:

: 925211-06-9,925211-07-0
bicyclo(3.2.0)hept-2-en-6-one

: 1623755-30-5
methyl-3-((1S,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium tetrahydroborate / methanol / 1.25 h / -78 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

3.1: potassium dihydrogenphosphate / tert-butyl methyl ether; pentane / 20 °C / pH 7 / Resolution of racemate; Enzymatic reaction

4.1: lithium hydroxide monohydrate / methanol; water / 0.5 h / 20 °C

5.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

6.1: ozone / dichloromethane; methanol / -78 °C

6.2: dehumidified air / 3 h / -78 - 20 °C

7.1: dmap; pyridine / dichloromethane / 2 h / -42 °C / Inert atmosphere

8.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Inert atmosphere; Reflux

9.1: potassium carbonate / dichloromethane; methanol / 1 h / Inert atmosphere

10.1: zinc / tetrahydrofuran / 0.5 h / 40 °C / Inert atmosphere; Reflux

11.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / Inert atmosphere; Reflux

With pyridine; 1H-imidazole; dmap; sodium tetrahydroborate; potassium dihydrogenphosphate; lithium hydroxide monohydrate; potassium carbonate; ozone; zinc; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; N,N-dimethyl-formamide; pentane; 10.1: |Barbier Coupling Reaction;
DOI:10.1002/anie.201400617